STATE OF MINERAL MOTION AND METABOLIC FUNCTION OF BONE TISSUE IN PATIENTS WITH DIABETES MELLITUS IN COMBINATION WITH OBESITY
Keywords:mineral metabolism, bone remodeling, diabetes, obesity.
There are currently many controversial issues regarding the effects of obesity (AD) and type 2 diabetes mellitus (DM) on bone metabolism, which determines bone mineral density. According to some researchers, coolant is a trigger, the most common and early marker of violations of these processes. Other scientists believe that coolant is to some extent a factor in protecting bone tissue, which causes an increase in bone mineral density.
Quite informative indicators that characterize the process of bone remodeling are considered to be the content in the blood of the bone isoenzyme alkaline phosphatase, the daily level of excretion of deoxypyridinoline, N-osteocalcin blood. However, it should be noted that most studies on bone metabolism in coronary heart disease and type 2 diabetes study this issue in postmenopausal women, while the perimenopausal period is not given enough attention, and there are no unambiguous data on gender differences in bone metabolism in persons under the age of 50 with coronary heart disease and type 2 diabetes.
Therefore, the aim of this study was to detail the sexual characteristics of markers that characterize the process of bone remodeling and mineral metabolism in patients with type 2 diabetes mellitus in combination with obesity.
During the study, a survey of 71 patients aged 42 to 50 years with coolant 1-2 tbsp. and type 2 diabetes (men/women - 29/42). The subjects were in a state of subcompensation of carbohydrate metabolism.
Examination of patients included measurement of anthropometric parameters, calculation of body mass
index and the ratio of waist circumference to hip circumference, study of carbohydrate metabolism parameters, determination of 25 (OH) D, magnesium, phosphorus, total and ionized blood calcium levels. The processes of bone formation were analyzed by the content of bone isoenzyme alkaline phosphatase, bone resorption was assessed by the daily level of excretion of deoxypyridinoline. The level of N-Osteocalcin (ng/ml) was also determined.
Analysis of the results of this study showed that even before the hormonal adjustment of the reproductive system in the vast majority of women and men with such a combined pathology as coolant and type 2 diabetes, a negative bone balance is formed due to disorders of calcium-phosphorus-magnesium metabolism, against vitamin D deficiency.
It is proved that complex interactions of disorders of mineral metabolism and pathogenetic factors, which are the basis of obesity and type 2 diabetes, are a condition for the formation of disorders of bone remodeling with increased resorptive activity in insufficient bone formation.
The results of this study are a priority in determining the sexual characteristics of mineral metabolism and bone remodeling processes in the Ukrainian population with coronary heart disease and type 2 diabetes.
An important achievement of the work is the clarification of changes in N-Osteocalcin in the studied category of patients, taking into account the main anthropometric parameters of the subjects and the parameters of carbohydrate metabolism.
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