MICRO- AND MACRONUTRIENT METABOLISM IN PATIENTS WITH NON-ALCOHOLIC FAT T Y LIVER DISE ASE AND IN COMBINATION WITH TYPE 2 DIABETES MELLITUS
Keywords:type 2 diabetes mellitus, non-alcoholic fatty liver disease, trace elements, macronutrients.
The purpose is to study changes in the concentration of zinc, magnesium, iron, calcium, potassium, sodium, copper, as well as to find out the relationship between the concentrations of micro - and macronutrients with liver function indicators in patients with non-alcoholic fatty liver disease (NAFLD) and in combination with type 2 diabetes mellitus (DM), depending on body mass index (BMI). 75 patients with (NAFLD) and in combination with type 2 DM - with normal body weight and obesity, aged 46 to 69 years, including 36 men and 39 women, with a duration of the disease from 3 to 15 years were examined. The control group consisted of 20 practically healthy people. The study program included determination of general clinical indicators, determination of the imbalance of bioelements, carbohydrates, proteins, assessment of the structural and functional state of the liver.
Results. The study of the bioelements composition of blood serum in all groups of patients showed a significant decrease in the content of zinc, magnesium, calcium, iron, potassium and sodium, as well as an increase in the copper especially in the group of patients with an increased BMI.
Conclusions. As a result of the study, a violation of the microcomposition of blood serum was revealed in all groups of patients. A significant decrease in the content of zinc, magnesium, calcium, iron, potassium and sodium, as well as an increase in the copper , was determined. A relationship was found between bioelements concentrations and liver function indicators in patients with NAFLD and in combination with type 2 DM, depending on BMI. With the combined course of NAFLD and type 2 DM in the presence of obesity, changes in, carbohydrate and protein metabolism, and the functional state of the liver were more pronounced.
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