FEATURES OF THE COLLAGEN EXPRESSION IN NODAL NEOPLASM OF THE THYROID GLAND

Authors

  • Khaziev V. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2013.2.06

Keywords:

nodular goiter, thyroid cancer, immunohistochemistry, collagens

Abstract

It was determined features of the collagen expression for different types of colloid goiter, follicular
adenomas and malignant thyroid tumos. The data was obtained that malignant thyroid tumos were
characterized by the low content of types I and III interstitial collagen in the stroma of tumor, the
appearance of is unusual for normal stroma type IV collagen and the marked shortage of type IV
collagen in the epithelial basement membrane. The "footprints"of type IV collagen were determined
in the malignancy areas of follicular adenomas, which are typical for malignant thyroid tumos and
can be used as a marker in the differential diagnosis of nodal neoplasm of the thyroid gland.

References

Endocrine Practice 2006; 2(1):78–84.

Rojeski MT, Gharib H. N Engl J Med 1985; 313:428-436.

Dedov II, Troshina EA, Aleksandrova GF, Moskva, 1999:48 p.

Larin AS, Cheren’ko SM. Vestnik Khirurgii im. II. Grekova 2008; 3:54-58.

Tron’ko M, Bogdanova T, Likhtarev I, et al. Radiation Health Risk Sciences, Tokio, Berlin, Heidelberg, New-York, 2009:305-316.

Gul’chij MV. Visnyk Naukovyh Doslidzhen’ 2005; 1:161–165.

Bogdanova TI, Zurnadzhy LYu, Tomas Dzh, et al. Svit Medytsyny ta Biologiyi 2008; 2:17-19.

Tron’ko M, Bogdanova T, Lihtar’ov I, et al. Tezy dop. mizhnar. nauk.-prakt. konf. z pytan’ sotsial’nogo zahystu gromadyan, yaki postrazhdaly vnaslidok Chornobyl’s’koyi katastrofy, Kyiv, 2008:83-84.

Cherenko S, Larin A, Gorobeyko M, Sichinava R. World J Surg 2004; 28:1071–1074.

Kogan EA. Mezhkletochnye vzaimodeystviya, Moskva, 1995:127-189.

Kogan EA. Patologicheskaya anatomiya: Kurs lektsiy, Moskva, 1998:247-262.

Kogan E.A. Patologicheskaya anatomiya: Kurs lektsiy, Moskva,1998:224-247.

McKinnell, et al. Biological Basis of Cancer, USA, 1998.

Cancer Medicine, Baltimor, 1997; 1,2.

Kopnin BP, available at: www.rosoncoweb.ru/library /01/02.htm.

Dabbs DJ. Diagnostic Immunohistochemistry, Elsevier, 2006:828 p.

Raykhlin NT, Petrov SV, Chairkin IN. Rukovodstvo po immunogistokhimicheskoy diagnostike opukholey cheloveka, Kazan’, 2000:12-14.

Petrov SV, Raykhlin NT, Rukovodstvo po immunogistokhimicheskoy diagnostike opukholi, Kazan’, 2004:110-117.

Downloads

Published

2013-06-18

How to Cite

Khaziev, V. V. (2013). FEATURES OF THE COLLAGEN EXPRESSION IN NODAL NEOPLASM OF THE THYROID GLAND. Problems of Endocrine Pathology, 44(2), 39-45. https://doi.org/10.21856/j-PEP.2013.2.06

Issue

Section

CLINICAL ENDOCRINOLOGY