THE EFFECT OF LIPOFLAVON ® ON BLOOD GLUCOSE LEVEL AND VASCULAR DYSFUNCTION IN DIABETIC RATS
DOI:
https://doi.org/10.21856/j-PEP.2013.4.05Keywords:
experimental diabetes, aorta, vascular dysfunction, endothelium-dependent vasodilatation, K-current, Lipoflavon, QuercetinAbstract
In an experiment in rats with streptozotocin-induced diabetic found that long intraperitoneal administration of a Lipoflavon®at a concentration of 1.4 mg/kg (in the recalculation on the active ingredient Quercetin) leads to a decrease in blood glucose levels, contributes to increase the total effluent K+-current to isolated smooth muscle cells, as well as normalization of endothelium-dependent vasodilation of isolated aortic ring segments. At the same time Lipoflavon®eliminates oscillations of vascular tone in diabetic animals and has a positive effect on Ca2+ — sensitization of myofilaments.
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