GENETIC VARIANTS OF ADIPONECTIN AND THERAPEUTIC EFFICIENCY OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN PATIENTS TYPE 2 DIABETES MELLITUS

Authors

  • Gorshunska M. Yu. Kharkiv Postgraduate Medical Academy https://orcid.org/0000-0002-4402-9441
  • Karachentsev Yu. I. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0003-1317-6999
  • Kravchun N. O. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Jansen E. National Institute for Public health and the Environment, Bilthoven, Netherlands
  • Atramentova L. O. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Gladkih O. I. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Krasova N. S. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0002-7113-7616
  • Leshchenko Zh. A. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0002-6141-689X
  • Tyzhnenko T. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Opaleiko Y. A. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Pochernyaev A. K. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Роltorak V. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0002-3717-4413

DOI:

https://doi.org/10.21856/j-PEP.2013.1.01

Keywords:

type 2 diabetes mellitus, adiponectin gene polymorphism, omega-3 polyunsaturated fatty acids, therapy

Abstract

In 61 type 2 diabetic patients it was defined single nucleotide polymorphism +276 G > T (rs1501299 ) in adiponectin gene and atherogenic potential dynamics (hormonal and metabolic parameters of insulin resistance, a pro-inflammatory state, oxidative status, adipokines) after daily administration for 12 weeks of omega-3 polyunsaturated fatty acids (Omacor) with the constant pattern of antidiabetic therapy. After the treatment, in all the surveyed it was revealed reduction of insulin resistance, while a significant increase in the levels of total adiponectin, total erythrocyte glutathione, as well as reduced levels of circulating insulin and osteoprotegerin were observed only in carriers of GG-genotype. These results suggest that genetic variations in the adiponectin gene can affect the therapeutic efficacy of omega-3 fatty acids, namely, to reduce the pattern of cardiovascular risk factors in type 2 diabetic patients in a Ukrainian population.

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Published

2013-03-25

How to Cite

Gorshunska, M., Karachentsev, Y., Kravchun, N., Jansen, E., Atramentova, L. O., Gladkih, O., Krasova, N., Leshchenko, Z., Tyzhnenko, T. V., Opaleiko, Y. A., Pochernyaev, A. K., & Роltorak V. V. (2013). GENETIC VARIANTS OF ADIPONECTIN AND THERAPEUTIC EFFICIENCY OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN PATIENTS TYPE 2 DIABETES MELLITUS. Problems of Endocrine Pathology, 43(1), 5-14. https://doi.org/10.21856/j-PEP.2013.1.01

Issue

Section

CLINICAL ENDOCRINOLOGY

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