SINGLE NUCLEOTIDE POLYMORPHISM OF ADIPONECTIN GENE (+276G > T) AND EXPRESSION OF INSULIN-RESISTANT STATE COMPONENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Authors

  • Gorshunska M. Yu. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine https://orcid.org/0000-0002-4402-9441
  • Karachentsev Yu. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv; Kharkiv Postgraduate Medical Academy https://orcid.org/0000-0003-1317-6999
  • Kravchun N. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Atramentova L. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gladkih A. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Krasova N. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv https://orcid.org/0000-0002-7113-7616
  • Leshchenko Zh. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv https://orcid.org/0000-0002-6141-689X
  • Tyzhnenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Opaleiko Yu. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Pochernyayev A. K. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Poltorak V. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2013.2.01

Keywords:

single nucleotide polymorphism, adiponectin gene, type 2 diabetes mellitus, insulin resistance

Abstract

Single nucleotide polymorphism +276G > T of adiponectin gene (ADIPOQ) in type 2 diabetes
mellitus patients (n=544) and healthy habitants (n = 215) of Kharkiv was studied. There were
no significant differences of single nucleotide polymorphism +276 G > T frequencies for patients
(pG = 0.691; pT = 0,309) and healthy subjects (pG = 0,601; pT = 0,399). However diabetic patients had
increased percentage of homozygote TT and decreased percentage of homozygote GG. Homozygosity
in the minor allele T enhances significantly risk of disease in general population (OR 1,98; 95 %
CI 1,14–3.32, p < 0.05) and homozygosity in the major allele G creates protective effect (OR 0,66; 95 %
CI 0,48–0.90, p < 0.05). Functional meaning of single nucleotide polymorphism in the locus +276G > T
of ADIPOQ gene for hypoadiponectinemia genesis was verified as complementary to determining
impact of diabetic endophenotype (hyperinsulinemia, insulin resistance, gluco- and lipotoxicity, central
type of fat distribution).

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Published

2013-06-18

How to Cite

Gorshunska, M., Karachentsev, Y., Kravchun, N., Atramentova, L. A., Gladkih, A. I., Krasova, N., Leshchenko, Z., Tyzhnenko, T. V., Opaleiko, Y. A., Pochernyayev, A. K., & Poltorak, V. V. (2013). SINGLE NUCLEOTIDE POLYMORPHISM OF ADIPONECTIN GENE (+276G > T) AND EXPRESSION OF INSULIN-RESISTANT STATE COMPONENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. Problems of Endocrine Pathology, 44(2), 7-17. https://doi.org/10.21856/j-PEP.2013.2.01

Issue

Section

CLINICAL ENDOCRINOLOGY

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