FERTILITY OF MALE RATS — OFFSPRING AFTER FATHER’S PHYTOESTROGENS EXPOSURES AND IT CHANGES AT CONDITIONS OF ADDITIONAL PHYTOESTROGENIZATION SUCH OFFSPRING IN THE CRITICAL PERIOD OF ONTOGENESIS

Authors

  • Selyukova N. Yu. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2014.1.07

Keywords:

male rats, phytoestrogenization, offspring, fertility, spermatogenesis, sex steroids

Abstract

In an experiment on rats were studied the effects of father’s phytoestrogenization (PE) (a mixture of PE at a dose of 20 mg/kg) in preconsumatory period (30 days) for his offspring by index of fertility, spermatogenesis, hormonal state. It was found that on the 5th day of life in the male offspring of father PE testosterone spike decreases and in reproductive age increases the estradiol level, the fertility decreased in half, but without change of semen characteristics. The data indicate that an excess of estrogen-like substances in the diet of male-father can affect on the reproductive function of their offspring. In offspring of PE fathers after additional phytoestrogenization in dairy period were found more expressed disorders of fertility, functional characteristics of sperm and hyperestrogenemia than after additional phytoestrogenization of intact father offspring. It was concluded that phytoestrogenization of father increase the sensitivity of male offspring to influence of the PE during critical periods of development.

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Published

2014-03-12

How to Cite

Selyukova, N. Y. (2014). FERTILITY OF MALE RATS — OFFSPRING AFTER FATHER’S PHYTOESTROGENS EXPOSURES AND IT CHANGES AT CONDITIONS OF ADDITIONAL PHYTOESTROGENIZATION SUCH OFFSPRING IN THE CRITICAL PERIOD OF ONTOGENESIS. Problems of Endocrine Pathology, 47(1), 55-62. https://doi.org/10.21856/j-PEP.2014.1.07