THYROID STATUS, MAJOR AND TRACE ELEMENTS CONTENT IN PATIENTS WITH AUTOIMMUNE THYROIDITDIS LIVING IN CHERNOBYL-AFFECTED AREAS OF ZHYTOMYR REGION

Authors

  • Luzanchuk I. A. Institute of endocrinology and metabolism of NAMS of Ukraine, Kyiv, Ukraine
  • Kravchenko V. I. Institute of endocrinology and metabolism of NAMS of Ukraine, Kyiv, Ukraine
  • Polumbryk M. O. National University of food technologies, Kyiv, Ukraine
  • Tarashchenko Yu. M. National University of food technologies, Kyiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.3.07

Keywords:

iodine deficiency, thyroid gland, autoimmune thyroiditis, urinary iodine excretion, thyroid dose, trace elements, relative risk

Abstract

Fifteen patients with autoimmune thyroiditis (AIT) and 45 individuals without thyroid pathology comprising control group were examined for the Ca, Mg, Zn, Fe, I, Se, Cu, thyroid dose, and thyroid status in the biological samples (blood serum and urine). The AIT group was exposed to radioactive doses of radiation, which exceed 1 Gy, whereas participants in the control group were exposed to less than 0.3 Gy during Chernobyl disaster. The individuals mentioned above participated in the cohort of US-Ukrainian-Belorussian collaborative project, and their blood samples were obtained from the database. In the present study, thyroid gland sizes were examined using a real-time portable scanner (Terason 2000, Burlington, MA, USA) with linear transducer, and frequency of 10 MHz. Iodine concentration in urine samples was measured by Sandell-Kolthoff reaction with the Dunn`s modification. Thyroid hormones status was assessed by concentrations of: thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroglobulin (Tg) in serum by radioimmunoassay analysis. Concentration of thyroglobulin antibodies (TgAbs) and thyroxine peroxidase antibodies (TPOAb) were measured in serum by immunochemiluminescence assays. Significantly higher parameters of the thyroid gland volume (Tvol), thyroxine peroxidase antibodies (TPOAb), and thyroid stimulating hormone (TSH) in blood serum were observed in the patients with AIT as compared to the control group. The median level of urinary iodine excretion urine (UIE) in the AIT group was significantly higher (p < 0.05) as compared to control group, which indicated the presence of mild iodine deficiency in the AIT group. Concentrations of calcium, magnesium, zinc, copper, iron, and selenium in serum were determined by atomic optical emission spectrometry coupled by inductively coupled plasma (ICP-OES, Perkin-Elmer, model Optima 2100, USA). In this study, patients with AIT had statistically significant (p < 0.001) lower level of Mg, Ca, Zn, and Cu in blood serum than in the control group. The relative risk (RR) of AIT development AIT low magnesium content in blood serum (p < 0.001) was RR = 5.4 (95 % CI 2.7–8.8), AIT low calcium content relative risk of AIT was 2.9 (95 % CI 1.8–3.6) (р < 0.001), and AIT low zinc content RR of AIT was found to be 2.3 (95 % CI 1.6–2.6) (р < 0.01).

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Published

2021-08-17

How to Cite

Luzanchuk, I. A., Kravchenko, V. I., Polumbryk, M. O., & Tarashchenko, Y. M. . (2021). THYROID STATUS, MAJOR AND TRACE ELEMENTS CONTENT IN PATIENTS WITH AUTOIMMUNE THYROIDITDIS LIVING IN CHERNOBYL-AFFECTED AREAS OF ZHYTOMYR REGION. Problems of Endocrine Pathology, 73(3), 54-61. https://doi.org/10.21856/j-PEP.2020.3.07

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Section

CLINICAL ENDOCRINOLOGY

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