CORRECTION OF THE IMPAIRED GLUCOSE TOLERANCE IN THE ELDERLY. FOCUS — INHIBITORS OF THE DIPEPTIDYL PEPTIDASE-IV (REVIEW AND OWN DATA)
DOI:
https://doi.org/10.21856/j-PEP.2014.3.14Keywords:
type 2 diabetes, glucose tolerance disorders, pre-diabetic state, elderly, therapy, SaksagliptinAbstract
In order to study the effect of Saksagliptin on the indicators of the functional activity of the
pancreas islets and indicators of glucose-insulin homeostasis in elderly patients with impaired glucose
tolerance examined 69 people aged 60 years and older. It was carried out a standard glucose tolerance
test, determined the content of glucose and insulin, calculation of insulin resistance index, the index
of insulin sensitivity, functional activity β -cells of the pancreas, the area under curve of glucose, it
was determined insulin and C-peptide. From the total group in the result of screening were selected
12 people with impaired glucose tolerance, which for the correction of violations during four weeks
of the treatment by Saksagliptin 5 mg per day. Usage of Saksagliptin led to normalization of glucose
tolerance in 9 out of 12 people (75 %), that indicating of the normalizing effect of DPP-IV inhibitors
in patients with glucose metabolism violation. Also it was indicated decrease of the insulin resistance
index and increase of insulin sensitivity index (Matsuda index). It was concluded that the use of
Saksagliptin is a perspective for the correction of pre-diabetic disorders of glucose metabolism in the
elderly.
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