SIRTUINS AS PERSPECTIVE TARGET FOR PREVENTION AND TREATMENT OF DIABETES
DOI:
https://doi.org/10.21856/j-PEP.2014.3.13Keywords:
type 2 diabetes, sirtuin, alpha-lipoic acid.Abstract
The review is devoted to the role of sirtuins, particularly SIRT1, in the regulation of processes
involved in the pathogenesis of obesity, insulin resistance, type 2 diabetes and its vascular complica-
tions. Proved the perspectivity of SIRT1 use as a therapeutic target for patients with diabetes, and
also describes a mechanism for activating SIRT1 in vitro and in vivo by alpha-lipoic acid.
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