WEIGHT INDICATORS AND HISTOLOGICAL STRUCTURE OF RAT FEMUR OFFSPRING OF STRESSED MOTHERS AT GESTATIONAL CHANGES OF ESTROGEN AND LEPTIN SYSTEM LEVELS

Authors

  • Sergiyenko L. Yu. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Seluykova N. Yu. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Cherevko A. N. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Bondarenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Perets O. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharki
  • Tolmachova L. N. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2015.2.14

Keywords:

gestational stress, offspring, obesity, osteopathies.

Abstract

It was established antenatal origin and pathogenetic affinity of obesity and osteopathies. It was reviewed leptin’s participation at the development of these pathologies. It was shown that high levels of leptin which inherent of gestational stressed mothers’ offspring activates hondro- and osteogenesis, increasing the reparative effects of estrogen in the locomotor’ system tissues. Moreover the excessive increase of systemic leptin’s level is a cause of pathological changes in cartilage and bone tissues which leads to the formation of osteophytes and sclerosis.

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Published

2021-08-18

How to Cite

Сергiєнко Л., Селюкова, Н., Черевко, Г. М., Бондаренко, Т. В., Перець, О. В., & Толмачова, Л. М. (2021). WEIGHT INDICATORS AND HISTOLOGICAL STRUCTURE OF RAT FEMUR OFFSPRING OF STRESSED MOTHERS AT GESTATIONAL CHANGES OF ESTROGEN AND LEPTIN SYSTEM LEVELS. Problems of Endocrine Pathology, 52(2), 101-109. https://doi.org/10.21856/j-PEP.2015.2.14

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