FEATURES OF ADIPOKINE PROFILE, HYPERINSULINEMIA AND DEGREE OF GLYCEMIC CONTROL IN RELATION WITH DAILY RATE OF BLOOD PRESSURE IN PATIENTS WITH TYPE 2 DIABETES AND OBESITY
DOI:
https://doi.org/10.21856/j-PEP.2014.2.02Keywords:
type 2 diabetes, obesity, arterial hypertension, daily rhythm of blood pressure, leptin, adiponectin, hyperinsulinemiaAbstract
The article presents the results of studying the level of adipokines (leptin and adiponectin), insulin levels, state of diabetes control (by fasting blood glucose and glycosylated hemoglobin), measurement of body mass index in 100 patients with type 2 diabetes, obesity and hypertension with different profiles of circadian rhythm of blood pressure (CRBP). In patients with type 2 diabetes in CRBP dipper type was associated with abdominal obesity degree 1, moderate hyperglycemia, normal level of insulinemia, hypoadiponectinemia and moderate hyperleptinemia. Type of CRBP over-dipper was associated with obesity degree 2, hypoadiponectinemia, expressed hyperleptinemia, moderate expressed hyperglycemia and hypoinsulinemia. Type of CRBP non-dipper was associated with abdominal obesity degree 1, low glycemic control, hyperinsulinemia, hypoadiponectinemia and moderate hyperleptinemia. Type of CRBP night-peaker was associated with obesity degree 2, hypoadiponectinemia, expressed hyperleptinemia, low glycemic control and hyperinsulinemia.
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