THE IMPACT OF COMPLEX DRUG KRATAL ON THE FUNCTIONAL STATE OF CARDIOVASCULAR SYSTEM IN RATS WITH METABOLIC SYNDROME

Authors

  • Ivanova O. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv https://orcid.org/0000-0002-2807-8729
  • Zvyagina T. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gorbenko N. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv https://orcid.org/0000-0001-6598-730X
  • Shalamay A. S. PJSC SIC «Borshchahivskiy CPP», Kiyev

DOI:

https://doi.org/10.21856/j-PEP.2015.2.13

Keywords:

Kratal, taurine, metabolic syndrome, fructose.

Abstract

It was investigated the effect of the drug Kratal on functional state of cardiovascular system in male rats with metabolic syndrome induced by chronic supplementation with high fructose diet. It was established that Kratal reveals cardio protective effect in rats with metabolic syndrome due to restore the normal heart rhythm and atrioventricular conduction, positive impact on systolic and diastolic heart activity and suppression of sinus tachycardia and ischemic processes development.

References

Akki A, Seymour A. Cardiovasc Res 2009; 81:610-617.

Babushkina AV. Ukr med chasopys 2010; 4(78):60-66.

Schaffer SW, Jong CJ, Junichi RKC, et al. J Biomed Sci 2010; 17(1):1-8.

Pansani MC, Azevedo PS, Murino Rafacho BP, et al. Plos One 2012; 7(7):1-6.

Patent 101418 UA. Farmacevtychna kompozycija, zasib dlja profilaktyky ta likuvannja metabolichnogo

syndromu ta diabetychnoi’ nefropatii’ ta sposib jogo otrymannja.

Lowndes J, Sinnett S, Yu Z, Ripp J. Nutrients 2014; 6:3153-3168.

Zagal’ni etychni pryncypy eksperymentiv na tvarynah. Endokrynologija 2003; 8(1):142-145.

Levi B, Werman M. J Nutrition 1998; 128(8):1442-1449.

Bazett HC. Heart 1920; 7(3):353-370.

Glans S. Mediko-biologicheskaja statistika, Moskva, 1998: 459 p.

Inoue T, Iseki K, Iseki C, et al. Circ J 2008; 72:454‑457.

East HE, et al. Diabetes Care 2005; 28:385‑390.

Momomura S, Bradley AB, Grossman W. Circ Res 1984; 55(2):203‑214.

Angelis K, Senador DD, Mostarda C, et al. Amer J Physiol 2012; 302(8):950-957.

Primenenie preparata Kratal v kompleksnoj terapii bol’nyh s ishemicheskoj bolezn’ju serdca

i nejrocirkuljatornoj distoniej, available at: http://bcpp.com.ua.

Kratal — novyj preparat otechestvennogo proizvodstva s kardioprotektornym dejstviem, available at: http://www.apteka.ua /article /11885.

Mieghem CV, et al. PhDCHEST 2004; 4:125.

Hayes E, Pugsley MK, Penz WP, et al. J Pharmacol Toxicol Methods 1994; 32(4):201-207.

Xu YJ, Arneja AS, Tappia PS, Dhalla NS. Exp Clin Cardiol 2008; 13(2):57-65.

Normann S, Priest R, Benditt E. Circ Res 1961; 9:282-287.

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Published

2015-06-26

How to Cite

Iванова О., Звягiна Т. С., Горбенко, Н., & Шаламай, А. С. (2015). THE IMPACT OF COMPLEX DRUG KRATAL ON THE FUNCTIONAL STATE OF CARDIOVASCULAR SYSTEM IN RATS WITH METABOLIC SYNDROME. Problems of Endocrine Pathology, 52(2), 94-100. https://doi.org/10.21856/j-PEP.2015.2.13

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