APOPTOSIS OF PANCREATIC BETA-CELLS AS A NEW TARGET FOR INSULIN THERAPY OF PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS

Authors

  • Poltorak V. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Krasova N. S. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy; Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2015.1.12

Keywords:

apoptosis, pancreatic beta-cells, diabetes mellitus, insulin analogues

Abstract

There is a review of the mechanisms of pancreatic beta-cell programmed death (apoptosis) in type 1 and 2 diabetes mellitus. Based on the evidence of anti-apoptotic physiological effects of insulin the necessity of new therapeutic strategy focused on maximal beta-cell function and mass preserving in diabetic patients using modern effective insulin therapy regimen is ground. The advantages of the both long- and short-acting insulin analogues (Lantus® and Apidra®) for early aggressive and safe glucose lowering therapy warranted to beta-cell preservation are argued.

References

Meier JJ, Bhushan A, Butler AE, et al. Diabetologia 2005; 48:2221-2228.

Butler AE, Janson J, Bonner-Weir S, et al. Diabetes 2003; 52:102-110.

Bernard-Kargar C, Ktorza A. Diabetes 2001; 50(1):S30-S35.

Robertson PR, Harmon J, Tran PO, Poitout V. Diabetes 2004; 53(1):S119-S124.

Polonsky KS. Int J Obes Relat Metab Disord 2000; 24(2):S29-S31.

Bonner-Weir S. J Mol Endocrinol 2000; 24:297-302.

Bonner-Weir S. Trends Endocrinol Metab 2000; 11:375-378.

Dickson LM, Rhodes J. Am J Physiol Endocrinol Metab 2004; 287:E192-E198.

Bonner-Weir S. Endocrinology 2000; 141:1926-1929.

Cnop M, Welsh N, Jonas JC, et al. Diabetes 2005; 54(2):97-107.

Butler AE, Galasso R, Meier JJ, et al. Diabetologia 2007; 50:2323-2331.

Meier JJ. Diabetologia 2008; 51:703-713.

Yuan J, Shaham S, Ledoux S, et al. Cell 1993; 75:641-652.

Shi Y. Protein Science 2004; 13:1979-1987.

Pirot P, Cardozo AK, Eizirik DL. Arq Bras Endocrinol Metab 2008; 52(2):156-165.

Pearl-Yafe M, Kaminitz A, Yolcu ES, et al. Curr Pharm Des 2007; 13:749-760.

Kawasaki E, Abiru N, Eguchi K. Diabetes Res Clin 2004; 66(1):S27-S32.

Savinov AY, Tcherepanov A, Green EA, et al. Proc Natl Acad Sci USA 2003; 100:628-632.

Maedler K, Storling J, Sturis J, et al. Diabetes 2004; 53:1706-1713.

Ortis F, Pirot P, Naamane N, et al. Diabetologia 2008; 51:1213-1225.

Melloul D. Biochem Soc Trans 2008; 36(3):334-339.

Cardozo AK, Ortis F, Storling J, et al. Diabetes 2005; 54:452-461.

Pacher P, Beckman JS, Liaudet L. Physiol Rev 2007; 87:315-424.

Azevedo-Martins AK, Lortz S, Lenzen S, et al. Diabetes 2003; 52:93-101.

Song P, Wu Y, Xu J, et al. Circulation 2007; 116:1585-1595.

Chaudhari N, Talwar P, Parimisetty A, et al. Front Cell Neurosci 2014; 8(213):1-15.

Araki E, Oyadomari S, Mori M. Exp Biol Med 2003; 228:1213-1217.

Wajchenberg BL. Endocr Rev 2007; 28:187-218.

Grill V, Bjorklund A. Diabetes 2001; 50(1):S122-S124.

Donath MY, Halban PA. Diabetologia 2004; 47:581-589.

Robertson R, Zhou H, Zhang T, Harmon JS. Cell Biochem Biophys 2007; 48:139-146.

Maedler K, Carr RD, Bosco D, et al. J Clin Endocrinol Metab 2005; 90:501-506.

Kashyap S, Belfort R, Gastaldelli A, et al. Diabetes 2003; 52:2461-2474.

Yaney GC, Corkey BE. Diabetologia 2003; 46:1297-1312.

Poitout V, Robertson RP. Endocrinology 2002; 143:339-342.

Cnop M, Hannaert JC, Hoorens A, et al. Diabetes 2001; 50:1771-1777.

Lupi R, Dotta F, Marselli L, et al. Diabetes 2002; 51:1437-1442.

Maedler K, Oberholzer J, Bucher P, et al. Diabetes 2003; 52:726-733.

Roehrich ME, Mooser V, Lenain V, et al. J Biol Chem 2003; 278:18368-18375.

Wrede CE, Dickson LM, Lingohr MK, et al. J Biol Chem 2002; 277: 49676-49684.

DeFronzo RA. Diabetologia 2010; 53:1270-1287.

Westermark P, Andersson A,Westermark GT. Physiol Rev 2011; 91(3):795-826.

Hull RL, Westermark GT, Westermark P, Kahn SE. J Clin Endocrinol Metab 2004; 89:3629-3643.

Hoppener JW, Lips CJ. Int J Biochem Cell Biol 2006; 38:726-736.

Tomita T. Islets 2011; 3(4):166-174.

Newmeyer DD, Ferguson-Miller S. Cell 2003; 112:481-490.

Kroemer G. Biochem Biophys Res Commun 2003; 304:433-435.

Green DR, Kroemer G. Science 2004; 305:626-629.

Peinado JR, Diaz-Ruiz A, Fruhbeck G, Malagon MM. Proteomics 2014; 14(4-5):452-466.

Martin SD, McGee SL. Biochim Biophys Acta 2014; 1840(4):1303-1312.

Maedler K. Diab Obes Metab 2008; 10:408-420.

Maedler K, Sergeev P, Ris F, et al. J Clin Invest 2002; 110:851-860.

Tsai EB, Sherry NA, Palmer JP, Herold KC. Diabetologia 2006; 49:261-270.

The Diabetes Control and Complications Trial (DCCT) Research Group. Ann Intern Med 1998; 128:517-523.

Meier JJ, Lin JC, Butler AE, et al. Diabetologia 2006; 49:1838-1844.

Martens GA, Van de Casteele M. Antioxid Redox Signal 2007; 9:309-317.

Ricci C, Pastukh V, Mozaffari M, Schaffer SW. Can J Physiol Pharmacol 2007; 85:455-464.

DeFronzo RA. Ann Inter Med 1999; 131:281-303.

Rayman G, Souhami E. Diabetologia 2005; 48(1):Abstr. A4.

Garg SK, Rosenstock J,Ways K. Endocr Pract 2005; 11(1):11-17.

Porcellati F, Rossetti P, Pampanelli S, et al. Diab Med 2004; 21:1213-1220.

Yki-Jarvinen H, Juurinen L, Alvarsson M, et al. Diabetes Care 2007; 30:1364-1369.

Herwig J, Scholl-Schilling G, Bohles H. Diabetologia 2002; 45(2):A872.

Chase HP, Dixon B, Pearson J, et al. J Pediatr 2003; 143:737-740.

Deiss D, Kordonouri O, Hartmann R, et al. Pediatr Diabetes 2007; 8:157-162.

Brunton SA. Med Gen Med 2007; 9:38.

Porcellati F, Rossetti P, Busciantella RN, et al. Diabetes Care 2007; 30:2447-2452.

Porcellati F, Rossetti P, Busciantella RN, et al. Diabetologia 2007; 50(1):S25.

Rosenstock J, Davies M, Home PD, et al. Diabetologia 2008; 51:408-416.

Foody J. Unlocking potential: new advances in diabetes mellitus management: Program & abstracts a Sanofi-Aventis supported satellite symposium at EASD 2008, Rome, 2008: 32 p.

Sharplin P, Mehin N, McEwan P, et al. ADA 2007:2599.

Sharplin P, Mehin N, McEwan P, et al. ADA 2007:2593.

Hammer H, Klinge A. Int J Clin Practice 2007; 61:2009-2018.

Schreiber SA, Ferlinz K, Haak T, et al. Diab Technol Ther 2008; 10:121-127.

Leahy J, Dain MP, Rhoads GG, et al. ISPOR 2007:14.

Leahy J, Dain MP, Rhoads GG, et al. ISPOR 2007:15.

Levin P, Zhand Q, Mersey J, et al. ISPOR 2007:16.

Viardot A, Grey ST, Mackay F, Chisholm D. Endocrinology 2007; 148:346-353.

Owens DR. Diab Technol Ther 2013; 15(9):1-10.

Ryan EA, Imes S, Wallace C. Diabetes Care 2004; 27:1028-1032.

Sellers EA, Dean HJ. J Pediatr Endocrinol Metab 2004; 17:1561-1564.

Hu Y, Li L, Xu Y, et al. Diabetes Care 2011; 34(8):1848-1853.

Alvarsson M, Sundkvist G, Lager I, et al. Diabetes Care 2003; 26:2231-2237.

Gerstein HC, Bosch J, Dagenais GR, et al. N Engl J Med 2012; 367(4):319-328.

Tron’ko MD, Poltorak VV, Sokolova LK. Mizhnar Endokrynol Zhurn 2013; 1(49):15-22.

Lepore M, Pampanelli S, Fanelli C, et al. Diabetes 2000; 49(12): 2142-2148.

Becker RH. Diab Technol Ther 2007; 9:109-121.

Bolli GB, Songini M, Trovati M, et al. Nutr Metab Cardiovasc Dis 2009; 19(8):571-579.

White MF. Am J Physiol Endocrinol Metab 2002; 283:E413-E422.

Niessen M. Arch Physiol Biochem 2006; 112:65-73.

Rhodes CJ. Science 2005; 307:380-384.

Cox SL. Drugs Today 2005; 11(1):433-440.

Rakatzi I, Ramrath S, Ledwig D, et al. Diabetes 2003; 52(9):2227-2238.

Stammberger I, Seipke G. Diabetologia 2005; 48(1):A592.

Rakatzi I, Seipke G, Eckel J. Biochem Biohpys Res Commun 2003; 310:852-859.

Poltorak VV, Karachencev JuI, Gorshunskaja MJu. Probl Endokryn Patologii’ 2006; 1:1-8.

Ulrich H, Snyder B, Garg SK. Vasc Health Risk Manag 2007; 3:245-254.

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Published

2021-06-23

How to Cite

Poltorak, V. V., Krasova, N. S., & Gorshunska, M. Y. (2021). APOPTOSIS OF PANCREATIC BETA-CELLS AS A NEW TARGET FOR INSULIN THERAPY OF PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS . Problems of Endocrine Pathology, 51(1), 90-102. https://doi.org/10.21856/j-PEP.2015.1.12

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