FEATURES OF CHANGES IN CIRCADIAN RHYTHM OF CIRCULATING LEVELS OF INSULIN AND GLUCOSE IN THE METABOLIC SYNDROME INDUCED EXPERIMENTAL HYPOPINEALISM

Authors

  • Mishchenko T. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Gladkih A. I. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Poltorak V. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Bondarenko L. O. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2015.1.10

Keywords:

hypopinealism, metabolic syndrome, insulin, glucose, daily rhythm

Abstract

In the experimental study on young adult male rabbits it was found leveling of circadian rhythm in insulin concentration and violation of circadian pattern of glucose (inversion, which is replaced by leveling) in the dynamics of the formation of metabolic syndrome, which develops in the hypopinealism induced by long-term exposure to low-light in the dark. Change in the circadian rhythm of secretion of insulin, glucose, and hyperinsulinemia that result of chronic disturbance of natural light/dark cycle, are the basis of the manifestation of the metabolic syndrome in hypopinealism.

References

Morris CJ, Aeschbach D, Scheer FA. Mol Cell Endocrinol 2012; 349(1):91-104.

Tsang AH, Barclay JL, Oster H. J Mol Endocrinol 2014; 52:1-16.

Reiter RJ, Tan DX, Korkmaz A, et al. Ann Med 2012; 44(6):564-577.

Van Cauter E, Knutson KL. Eur J Endocrinol 2008; 159:59-66.

Gangwisch JE, Heymsfield SB, Boden-Albala B, et al. SLEEP 2007; 30(12):1667-1673.

Knutson KL, Van Cauter E, Rathouz PJ, et al. Arch Intern Med 2009; 169(1):1055-1061.

Helimskij AM. Jepifiz (shishkovidnaja zheleza), Moskva, 1969: 183 p.

Gubina-Vakulik GI, Bondarenko LA, Sotnik NN. Uspehi Gerontologii 2007; 20(1):92-95.

Bondarenko LO, Poltorak VV, Sergijenko LJu, et al. Inform Bjul Dodatok do «Zhurnalu AMN Ukrai’ny» 2009; 25:118-119.

Tasaka Y, Inoue S, Maruno K, et al. Endocrinol Japon 1980; 27(4):495-498.

Polonsky KS, Given BD, Van Cauter E. J Clin Invest 1988; 81:442-448.

Boden G, Ruiz J, Urbain J, et al. Am J Physiol 1996; 271(2):246-252.

Sadacca LA, Lamia KA, de Lemos AS, et al. Diabetologia 2011; 54:120-124.

Peschke E, Peschke D. Klin Neurophysiol 2010; 41(1):1085-1092.

Picinato MC, Haber EP, Carpinelli AR, et al. J Pineal Res 2002; 33:172-177.

Peschke E, Fauteck JD, Musshoff U, et al. J Pineal Res 2000; 28(3):156-164.

Patent 20383 UA. Sposib modeljuvannja involjutyvnyh procesiv u pineal’nij zalozi.

Shrejber V. Patofiziologija zhelez vnutrennej sekrecii, Praga, 1987: 493 p.

Mishhenko TV, Gladkyh OI, Poltorak VV, et al. Dosjagnennja ta perspektyvy eksperymental’noi’ i klinichnoi’ endokrynologii’: materialy nauk.-prakt. konf., Harkiv, 2014: 107-108 p.

Anhe GF, Caperuto LC, Pereira-Da-Silva M, et al. J Neurochemistry 2004; 90:559-566.

Ha E, Yim SV, Chung JH, et al. J Pineal Res 2006; 41(1):67-72.

Contreras-Alcantara S, Baba K, Tosini G. Obesity 2010; 18(9):1861-1863.

Kloting I, Bahr J, Wilke B, et al. Lab Anim 2013; 47(1):31-35.

Vinogradova IA. Uspehi Gerontologii 2007; 20(2):70-75.

Bondarenko LO, Sergijenko LJu, Cherevko GM, et al. Probl Endokryn Patologii’ 2014; 2:57-64.

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Published

2021-06-23

How to Cite

Mishchenko, T. V., Gladkih, A. I., Poltorak, V. V., & Bondarenko, L. O. (2021). FEATURES OF CHANGES IN CIRCADIAN RHYTHM OF CIRCULATING LEVELS OF INSULIN AND GLUCOSE IN THE METABOLIC SYNDROME INDUCED EXPERIMENTAL HYPOPINEALISM. Problems of Endocrine Pathology, 51(1), 73-79. https://doi.org/10.21856/j-PEP.2015.1.10

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