LEPTIN RESISTANCE AS A CAUSE OF LACK OF EATING BEHAVIOR CHANGES IN HYPERLEPTINEMIA AND OBESITY IN FEMALE RATS — OFFSPRING OF GESTATIONAL STRESSED MOTHERS

Authors

  • Sergiyenko L. Yu. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Perets O. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Seluykova N. Yu. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Bondarenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Cherevko A. N. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Tolmachova L. N. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Marakina A. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2014.3.10

Keywords:

gestational stress, offspring, leptin resistance, obesity

Abstract

In the experiment on Wistar rats was studied age dynamics of body weight in the postnatal period in the offspring of gestational stressed mothers, which was born with low weight and reduced levels of leptin in the blood plasma. It was shown that adult offspring of stressed mothers have increased body weight and visceral fat mass, increased levels of leptin in the blood compared to the offspring of intact mothers. However, by the number of food consumed offspring of stressed mothers did not differ from intact offspring. Long-term injection of exogenous leptin does not affect the eating behavior of offspring of stressed mothers, although inhibits the eating behavior the intact animals. It was concluded about availability of «economic type» energy metabolism and insulin resistance in the hypothalamic structures of offspring of gestational stressed mothers

References

Bilovol OM, Koval’ova OM, Popova SS, Tveretinov OB. Ozhyrinnja v praktyci kardiologa ta endokrynologa, Ternopil’, 2009: 618 p.

WHO. Obesity: preventing and managing the global epidemic, Geneva, 2000.

Hedley AA, Ogden CL, Jonson CL. JAMA 2002; 291:2847-2850.

Lezhenko GA. Ukrai’ns’ka shkola endokrynologii’:materialy 58-i’ nauk.-prakt. konf, Harkiv, 2014:79-86.

Fonseca-Alaniz MH, Takada J, Alonso-Vale MI, Lima FB. J Pediatr 2007; 83(5):S192-S203.

Bjorbaek C, Kahn BB. Recent Prog Horm Res 2004; 59:305-331.

Mantzoros CS. Ann Intern Med 1999; 130(8):671-680.

Kratzsch J, Höckel M, Kiess W. Curr Opin Obstet Gynecol 2000; 12(6):501-505.

Burguera B, Couce ME, Curran GL, et al. Diabetes 2000; 49(7):1219-1223.

Myers MG, Cowley MA, Münzberg H. Ann Rev Physiol 2008; 70:537-556.

Kalra SP. Peptides 2008; 29(1):127-138.

Shekhawat PS, Garland JS, Shivpuri C, et al. Pediatr Res 1998; 43(3):338-343.

Sergijenko LJu, Perec’ OV, Kartavceva OV. Sposib modeljuvannja gipertrofichno-giperplastychnogo typu ozhyrinnja z oznakamy zapalennja, Patent 53260 UA 2010; 18:7 p.

Hizhnjak OO, Sulima TN, Plehova EI, Kashkalda DA. Probl Endokryn Patologii’ 2007; 4:17-25.

Pratt NC, Lisk RD. J Reprod Fert 1989; 87:763-769.

Zapadnjuk IP, Zapadnjuk VI, Zaharija EI. Laboratornye zhivotnye, Kiev, 1974: 304 p.

Endokrynologija 2003; 8(1):142-145.

Janjuta SM, Dashkevich VS, Tarahovskij ML. Pediatrija, Akusherstvo i Ginekologija 1997; 5:65-68.

Barker DJP. Mothers, Babies and Disease in later Life, London, 1994: 348 p.

Lesage J, Del-Favero F, Leonhardt M, et al. J Endocrinol 2004; 181:291-296.

Sergijenko LJu. VIII Kongres Svitovoi’ Federacii’ Ukrai’ns’kyh Likars’kyh Tovarystv: tezy dop, L’viv, 2010: 398-399.

Murphy VE, Smith R, Giles WB, Clifton VL. Endocr Rev 2006; 27(2):141-169.

Vickers MH, Krechowec SO, Gluckman PD, Breier BH. Landes Bioscience, 2009; 14:141-161.

Sergijenko LJu, Perec’ OV, Kartavceva OV, et al. Probl Endokryn Patologii’ 2010; 3:83-89.

Tereshhenko IV, Gericenko IV. Probl Jendokrinologii 2001; 47(4):40-46.

Choi SJ, Sparks R, Clay M, Dallman MF. Endocrinology 1999; 140(10):4426-4433.

Downloads

Published

2014-10-27

How to Cite

Sergiyenko, L. Y., Perets, O. V., Seluykova, N. Y., Bondarenko, T. V., Cherevko, A. N., Tolmachova, L. N., & Marakina, A. V. (2014). LEPTIN RESISTANCE AS A CAUSE OF LACK OF EATING BEHAVIOR CHANGES IN HYPERLEPTINEMIA AND OBESITY IN FEMALE RATS — OFFSPRING OF GESTATIONAL STRESSED MOTHERS. Problems of Endocrine Pathology, 49(3), 73-80. https://doi.org/10.21856/j-PEP.2014.3.10

Issue

Vol. 49 No. 3 (2014): Problems of Endocrine Pathology

Section

EXPERIMENTAL STUDIES

Most read articles by the same author(s)

1 2 > >>