PECULIARITIES OF ENDOTHELIAL FACTORS IN PREGNANT WOMEN WITH PLACENTAL DYSFUNCTION AND DIABETES

Authors

  • Lazurenko V. V. Kharkiv National Medical University, Kharkiv, Ukraine
  • Tertyshnik D. Yu. Kharkiv National Medical University, Kharkiv, Ukraine; Kharkiv Regional Clinical Hospital, Kharkiv, Ukraine
  • Borzenko I. B. Kharkiv National Medical University, Kharkiv, Ukraine; Kharkiv Regional Clinical Hospital, Kharkiv, Ukraine
  • Kondratova I. Yu. Kharkiv Regional Clinical Hospital, Kharkiv, Ukraine
  • Ovcharenko O. B. Kharkiv National Medical University, Kharkiv, Ukraine
  • Safonov R. A. Kharkiv National Medical University, Kharkiv, Ukraine; Kharkiv Regional Clinical Hospital, Kharkiv, Ukraine
  • Pasiyeshvili N. M. Kharkiv Regional Clinical Perinatal Center, Kharkiv, Ukraine
  • Karpenko V. G. Karazin Kharkiv National University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.3.06

Keywords:

diabetes mellitus, placental dysfunction, endothelial factors

Abstract

The purpose is the early diagnosis of placental dysfunction in women with diabetes mellitus with the help of endothelial factors to optimize childbirth. Pregnancy and childbirth were analyzed in 94 pregnant women aged from 23 to 38. Pregnant women were divided into the following clinical groups: 30 pregnant women with diabetes (the first group), 34 pregnant women with diabetes and placental dysfunction (the second group) and 30 practically healthy pregnant women (the control group). During the 36–38th weeks of pregnancy, there was a significant decrease (p < 0.05) of serum CEFR indices in patients with placental dysfunction due to diabetes (69.3 ± 2.9 pg/ml), not only compared with those in women with physiological course of pregnancy (119.6 ± 5.2 pg/ml), but also in pregnant women with diabetes without placental dysfunction (87.4 ± 3.4 pg/ml) (p < 0.05). The ET-1 study showed a decrease in pregnant women with diabetes and placental dysfunction (0.97 ± 0.18 pg/ml) by almost three times compared with control group women (3.12 ± 0.41 pg/ml) and pregnant women with diabetes, but without placental dysfunction (1.54 ± 0.12 pg/ml), whose ET-1 level was two times lower than the control values (p < 0.05). There was also a decrease in the eNOS index for diabetes (from 58 pg/ml in pregnant women with diabetes and placental dysfunction to 68 pg/ml for diabetes, the norm is 79–82 pg/ml). Women with diabetes and placental dysfunction predominantly had the induced childbirth, almost half of which ended with a caesarean section. During the study we observed the following perinatal complications: shoulder dystocia due to macrosomia (19 %), hypoglycemia (15 %), jaundice (8 %), respiratory distress syndrome (5 %), perinatal mortality was 9.4 %. Changes in endothelial factors (VEGF, ET-1, eNOS) in the blood of pregnant women with diabetes mellitus may indicate the development of placental dysfunction, which requires immediate examination of the fetus and timely delivery using the induced childbirth to improve maternal and perinatal outcomes.

References

American Diabetes Association. Diabetes Care 2019; 42(1): S165-S172. https://doi.org/10.2337/dc19-S014.

Hyc’ A. Ukr Med Chasopys 2020; 1: 1670 http://www.umj.com.ua.

Committee on Practice Bulletins-Obstetrics. Obstet Gynecol 2018; 131(2): e49-e64. https://doi.org/10.1097/AOG.0000000000002501.

Avramenko T, Makarenko M, Govsieiev D. J Global Pharma Technol 2017; 11(9): 48-52.

Borzenko IB, Lazurenko VV. Mizhnar Med Zhurn 2019; 3: 33-37.

Ovcharuk VV. Kliniko-patogenetychni aspekty diagnostyky ta profilaktyky placentarnoi’ dysfunkcii’, Ternopil’, 2017: 213 p.

Jakovleva EA, Demina OV, Babadzhanjan EN, Jakovenko EA. Mizhnar Med Zhurn 2017; 2: 47-51.

Volik NK, Vdovichenko JuP, Babkina TM, Dykan IN. Promeneva dіagnostika, promeneva terapіja 2010; 1: 42-47.

Kon’kov DG, Galych SR, Belkanyja GS. Z turbotoju pro zhinku. Kyi’v 2013; 2: 64-67.

Dabrowski FA, Lipa M, Bartoszewicz Z, et al. J Matern Fetal Neonatal Med 2019; 15: 1-6. https://doi.org/10.1080/14767058.2019.1639666.

Takata Y, Nomura K, Ishibashi K, et al. Biol Pharm Bull 2019; 42(5): 807-813. https://doi.org/10.1248/bpb.b18-00998.

Safonova IN. Neonatologіja, hіrurgіja ta perinatal’na medicina 2016; 6(2): 74-83.

WHO recommendations for induction of labour, available at: http://whqlibdoc.who.int/hq/2011/WHO_RHR_11.10_eng.pdf.

Pardo F, Subiabre M, Fuentes G, et al. Mol Aspects Med 2019; 66: 40-48. https://doi.org/10.1016/j.mam.2019.02.003.

Downloads

Published

2021-08-17

How to Cite

Lazurenko, V. V., Tertyshnik, D. Y., Borzenko, I. B., Kondratova, I. Y., Ovcharenko, O. B., Safonov, R. A., Pasiyeshvili, N. M., & Karpenko, V. G. (2021). PECULIARITIES OF ENDOTHELIAL FACTORS IN PREGNANT WOMEN WITH PLACENTAL DYSFUNCTION AND DIABETES. Problems of Endocrine Pathology, 73(3), 47-53. https://doi.org/10.21856/j-PEP.2020.3.06

Issue

Section

CLINICAL ENDOCRINOLOGY