LATENT AUTOIMMUNE DIABETES OF ADULTS COMBINED WITH METABOLIC SYNDROME

Authors

  • Tykhonova T. M. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2014.3.02

Keywords:

latent autoimmune diabetes of adults, metabolic syndrome, combined pathology, course of the disease, glucose metabolism, lipid metabolism

Abstract

It was examined 121 patients with a diagnosis of latent autoimmune diabetes of adults (LADA), which in depending on the presence or absence of anthropometric markers of metabolic syndrome were divided into two groups. It was carried out a comparative analysis of anamnestic data, lipid and glucose metabolisms. In 20.66 % of LADA patients determined the presence of metabolic syndrome. It was established that LADA combined with metabolic syndrome is characterized by a higher frequency of hypertension, as well as a latent course manifestation of the disease. The presence of anthropometric clusters of metabolic syndrome in LADA patients accompanied by more stable level of glycemia on the background of insulin therapy and aggravates dyslipidemia, causing a significant increase in the blood levels of β-lipoproteins, triglycerides, very low-density lipoproteins, decreased high-density lipoprotein, increased atherogenic index.

References

Diabetes Care 2002: 21 p.

Lancet 1997; 350(1):1288-1293.

Zimmet PZ, Tuomi T, Mackay IR, et al. Diabetic Med 1994; 11:299-303.

Hosszúfalusi N, Vatay Á, Rajczy K, et al. Diabetes Care 2003; 26(2):452-457.

Tuomi T, Groop LC, Zimmet PZ, et al. Diabetes 1993; 42(2):359-362.

Djekic K, Mouzeyan A, Ipp E. J Clin Endocrinol Metabol 2012; 97(3):E409-413.

Li X, Huang G, Yan X, et al. Nan Fang Yi Ke Da Xue Xue Bao 2010; 30(6):1247-1249.

Lohmann T, Kellner K, Verlohren HJ, et al. Diabetologia 2001; 44(8):1005-1010.

Fourlanos S, Dotta F, Greenbaum CJ, et al. Diabetologia 2005; 48(11):2206-2212.

Hawa MI, Thivolet C, Mauricio DD, et al. Diabetes Care 2009; 32(1):160-164.

Zhou J, Ma XJ, Bao YQ, et al. Zhonghua Yi Xue Za Zhi 2009; 89(18):1250-1254.

Mollo A, Hernandez M, Marsal JRD, et al. Diab Metab Res Rev 2013; 29(6):446-451.

Adeleye OO, Ogbera AO, Fasanmade O, et al. Intern Arch Med 2012; 5(1):5-23.

Nikonova TV. Saharnyj diabet 1 tipa i latentnyj autoimmunnyj diabet vzroslyh (LADA): klinicheskie, immuno-geneticheskie i gormonal’nometabolicheskie aspekty, Moskva, 2011: 38 p.

Brahmkshatriya PP, Mehta AA, Saboo BD, Goyal RK. ISRN Pharmacol 2012, doi: http://doi.org/10.5402/2012/580202.

World Health Organization. Obesity: Preventing and managing the global epidemic. Technical report series no. 894, Geneva, 2000: 23 p.

JAMA 2001; 285(19):2486–2497.

Klimov ANb Nikul’cheva JuG. Obmen lipidov i lipoproteidov i ih narushenija, Sankt-Peterburg, 1999: 505 p.

Borovikov VP. Populjarnoe vvedenie v programmu STATISTICA, Moskva, 1998: 267 p.

Solov’eva OE. Osobennosti debjuta i razvitija sosudistyh oslozhnenij u bol’nyh medlenno progressirujushhim autoimmunnym diabetom vzroslyh, Moskva, 2002: 125 p.

Lutgens MW, Meijer M, Peeters B, et al. Poulsen MLPrim Care Diabetes 2008; 2(4):207-211.

Tyhonova TM. Probl Endokryn Patologii’ 2012; 1:16-25.

Kononenko IV, Prokof’ev SA, Smirnova OM. Probl Jendokrinologii 2004; 50(1):18-20.

Xia Li, Zhiguang Zhou, Gan Huang, Heng Su. et al. Metab Syndrome Related Dis 2005; 3(2):174-180.

Downloads

Published

2014-10-27

How to Cite

Tykhonova, T. M. (2014). LATENT AUTOIMMUNE DIABETES OF ADULTS COMBINED WITH METABOLIC SYNDROME. Problems of Endocrine Pathology, 49(3), 18-24. https://doi.org/10.21856/j-PEP.2014.3.02

Issue

Section

CLINICAL ENDOCRINOLOGY

Most read articles by the same author(s)

1 2 > >>