EFFECT OF POTENTIAL INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE OF TYPE 1 ON THE FUNCTIONAL-METABOLIC PARAMETERS IN RATS WITH EXPERIMENTAL TYPE 2 DIABETES MELLITUS
DOI:
https://doi.org/10.21856/j-PEP.2014.4.07Keywords:
type 2 diabetes mellitus, 11β-hydroxysteroid dehydrogenase type 1 inhibitor, insulin resistance, obesityAbstract
It has been established that the intragastric administration within 15 days of the heterocyclic compound AD-1408 — a potential enzyme inhibitor prereceptor exchange corticosteroids — 11β-hydroxysteroid dehydrogenase type 1 leads to improvement of glucose tolerance, increased of insulin sensitivity, reduced of blood pressure and weight of abdominal fat fractions in sexually mature Wistar male rats with experimental type 2 diabetes and obesity. The studied compound was not inferior and sometimes even exceeded by the effectiveness of influence than the effect of the reference drug metformin.
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