EFFECT OF POTENTIAL INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE OF TYPE 1 ON THE FUNCTIONAL-METABOLIC PARAMETERS IN RATS WITH EXPERIMENTAL TYPE 2 DIABETES MELLITUS

Authors

  • Krasova N. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Gladkih A. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Lipson V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Leshchenko Z. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Tyzhnenko T. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Opaleiko Y. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Zubatyuk T. SSI «Institute for Single Crystals» of NAS of Ukraine, Kharkiv
  • Svidlo I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Yaremenko F. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Poltorak V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2014.4.07

Keywords:

type 2 diabetes mellitus, 11β-hydroxysteroid dehydrogenase type 1 inhibitor, insulin resistance, obesity

Abstract

It has been established that the intragastric administration within 15 days of the heterocyclic compound AD-1408 — a potential enzyme inhibitor prereceptor exchange corticosteroids — 11β-hydroxysteroid dehydrogenase type 1 leads to improvement of glucose tolerance, increased of insulin sensitivity, reduced of blood pressure and weight of abdominal fat fractions in sexually mature Wistar male rats with experimental type 2 diabetes and obesity. The studied compound was not inferior and sometimes even exceeded by the effectiveness of influence than the effect of the reference drug metformin.

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Published

2014-12-08

How to Cite

Krasova, N., Gladkih, A., Lipson, V., Leshchenko, Z., Tyzhnenko, T., Opaleiko, Y., Zubatyuk, T., Svidlo, I., Yaremenko, F., & Poltorak, V. (2014). EFFECT OF POTENTIAL INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE OF TYPE 1 ON THE FUNCTIONAL-METABOLIC PARAMETERS IN RATS WITH EXPERIMENTAL TYPE 2 DIABETES MELLITUS. Problems of Endocrine Pathology, 50(4), 60-66. https://doi.org/10.21856/j-PEP.2014.4.07

Issue

Vol. 50 No. 4 (2014): Problems of Endocrine Pathology

Section

EXPERIMENTAL STUDIES