A HIGHLY SENSITIVE C-RE ACTIVE PROTEIN AND ITS REL ATIONSHIP WITH FE ATURES OF ARTERIAL HYPERTENSION IN PATIENTS WITH ABDOMINAL OBESITY

Authors

  • Koval S. M. GI «L.T. Malaya Therapy National Institute of the National Academy of Medical Science of Ukraine», Kharkiv, Ukraine
  • Mysnichenko O. V. GI «L.T. Malaya Therapy National Institute of the National Academy of Medical Science of Ukraine», Kharkiv, Ukraine
  • Penkova M. Yu. GI «L.T. Malaya Therapy National Institute of the National Academy of Medical Science of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.4.07

Keywords:

arterial hypertension, abdominal obesity, subclinical inflammation, high sensitivity C-reactive protein

Abstract

The aim: to study the nature of changes in the levels of highly sensitive C-reactive protein(hsCRP) in the blood in patients with arterial hypertension (AH) with abdominal obesity (AO) and their relationship with the characteristics of the course of the disease. Materials and methods. We examined 68 patients with stage II AH (40 men and 28 women) aged from 35 to 60 years (36 patients with AO and 32 –with normal body weight (NBW). The control group consisted of 22 apparently healthy individuals (13 men and 9 women) aged from 18 to 52 years. The survey included standard clinical, laboratory and instrumental methods. The blood levels of hsCRP were determined by the enzyme immunoassay. The data obtained were analyzed using the SPSS 19.0 computer program for Windows XP. Results. It was found that in patients with AH stage II with AO without cardiovascular and renal complications and concominant cardiovascular and renal diseases, a significant increase in blood levels of one of the powerful and sensitive markers of inflammation-hsCRP was revealed, both in comparison with practically healthy individuals, and with patients with AH, but with NBW. The highest blood levels of hsCRP are observed in hypertensive patients with AO with a more pronounced increase in blood pressure, with grade 3 hypertension, with subclinical target organ damage (TOD) specific for hypertension-left ventricular hypertrophy and prediabetes. Conclusions. In stage II AH, which proceeds against the background of AO, but still without any cardiovascular and renal complications and concominant cardiovascular and renal diseases, a pronounced increase in hsCRP production already occurs. An increase in the production of this pro-inflammatory factor can be initiated by both hemodynamic and metabolic changes and lead to early TOD.

References

Williams B, Mancia G, Spiering W, et al. Eur Health J 2018; 39(33): 3021-3104. doi: http://doi.org/10.1093/eurheartj/ehy339.

Zanchetti A. J Hypertens 2015; 33(3): 423-424. doi:http://doi.org/10.1097/HJH.0000000000000517.

Landsberg L, Arrone LJ, Beilin LJ, et al. J Clin Hypertens 2013; 15: 14-33.

Limareva LV, Ginzburg MM, Sazonova OV, et al. Voprosy Pitanija 2017; 1(86): 41-47.

Koval’ SM, Snigurs’ka IO, C’oma LM. Eksperym Klin Medycyna 2010; 4(49): 67-70.

Koval’ SM, Jushko KO, Starchenko TG, Myloslavs’kyj DK. Zhurn NAMN Ukrai’ny 2018; 4: 24-28.

Harrison DG, Guzik TJ, Lob HE, et al. Hypertension 2011; 57(2): 132-140. doi: http://doi.org/10.1161/HYPERTENSIONAHA.110.163576.

Hashimov ShH, Hajbullina ZR, Mahmudov UM, et al. Mezhdunar Zhurn Prikladnyh i Fundam Issled 2016;11(3): 468-472.

Koval’ SM, Malovіchko GM. Medichnі Perspektivi 2007;12(1): 20-24.

Koval S, Mysnychenko O, Snegurska I, et al. J Hypertens 2015; 33(1): 340.

Bisoendial RJ, Boekholdt SM, Vergeer M, et al. Eur Heart J 2010; 35: 2087-2091. doi: http://doi.org/10.1155/2014/605810.

Hage FG. J Hum Hypertens 2014; 28(7): 410-415. doi: http://doi.org/10.1038/jhh.2013.111.

Hanmurzaeva NB. Nauchnoe obozrenie. Med nauki 2016; 2: 109-112.

Himion LV, Rybyctka MJu, Tymoshhuk LS. Semejnaja Medicina 2018; 1(75): 55-57.

Barbaro NR, Harrison DG. Hypertens 2019; 73(4): 767-769. doi:http://doi.org/10.1161/HYPERTENSIONAHA.119.12604.

Kovalenko VM, Lutaj MI, Sirenko JuM, Sychov OS. Cercevo-sudynni zahvorjuvannja. Klasyfikacija, standarty

diagnostyky i likuvannja, Kyi’v, 2016: 192 p.

WHO: Obesity: Prevention and managing the global epidemic. Technical Report Series 894, Geneva, 2000.

Cosentino F, Grant PJ, Aboyans V, et al. Eur Heart J 2020; 41(2): 255-323. doi: http://doi.org/10.1093/eurheartj/ehz486.

Iwashima Y, Horio T, Kamide K, et al. Hypertens Res 2007; 30(12): 1177-1185. doi: http://doi.org/10.1291/hypres.30.1177.

Bozhko VV, Snigurs’ka IO, Myloslavs’kyj DK, et al. Aktual’ni Probl Suchasnoi’ Medycyny 2017; 1(57): 45-50.

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Published

2020-11-12

How to Cite

Koval, S. M., Mysnichenko, O. V., & Penkova, M. Y. (2020). A HIGHLY SENSITIVE C-RE ACTIVE PROTEIN AND ITS REL ATIONSHIP WITH FE ATURES OF ARTERIAL HYPERTENSION IN PATIENTS WITH ABDOMINAL OBESITY. Problems of Endocrine Pathology, 74(4), 60-65. https://doi.org/10.21856/j-PEP.2020.4.07

Issue

Section

CLINICAL ENDOCRINOLOGY