• Biliaieva K. S. National Pirogov Memorial Medical University, Vinnytsya, Ukraine;
  • Vlasenko M. V. National Pirogov Memorial Medical University, Vinnytsya, Ukraine;
  • Pashkovska N. V. Bukovinian State Medical University, Chernivtsi, Ukraine



vitamin D, type 1 diabetes, adolescents, carbohydrate metabolism


Based on current world data, vitamin D deficiency as well as insufficiency is one of the health problems
worldwide and has a global pandemic meaning for the population. Vitamin D is involved in many physiological processes that occur in the body, which are especially important during puberty, period of intensive growth
and a set of peak bone mass of the child. According to the latest data of vitamin D effects on the development
and prognosis of type 1 diabetes mellitus, the aim of the study was to determine the epidemiology of vitamin D
deficiency and insufficiency in adolescents with type 1 diabetes mellitus, as well as to assess the correlation
between levels of vitamin D and compensation of the disease. The study was conducted on the basis of the
Vinnitsya regional clinical highly specialized endocrinological center. The total number of examined patients
was 124 adolescents aged from 10 to 18 years (61 girls, 63 boys), including: 1 group — 91 adolescents with type 1
diabetes, 2 group — 33 healthy adolescents (16 girls, 17 boys). According to the results of the study, the majority
of adolescents with type 1 diabetes have a deficiency (69 %) or insufficiency (26 %) of vitamin D. Only 5 % of the
examined adolescents had normal levels of vitamin D. In the group of somatically healthy adolescents, normal
levels of vitamin D were observed in 15% of children. It has been established that the prevalence of vitamin D
deficiency in adolescents with type 1 diabetes mellitus is higher compared to healthy adolescents. Also it was
found that the bigger part of the patients with type 1 diabetes mellitus who has poor glycemic control had vitamin D deficiency. Further studies should be held for evaluation of glycemic control in adolescents with type 1
diabetes mellitus after normalization of vitamin D levels


Pludowski P, Holick MF, Pilz S, et al. Autoimmune Rev 2013; 12: 976-989. doi: 10.1016/j.autrev.2013.02.004.

Maydannyk VG. Klinichni recomendacii po diagnostici, likuvanny ta profilaktici vitamin D deficitnogo rahitu u ditey, Kiev, 2014: 58 p.

Guessous I. Biomed Res Int 2015; 2015: 563403. doi:

Chakhtoura M, Azar S. Int J Endocrinol 2013; 2013: 148673. doi: 10.1155/2013/148673.

Mathieu C. Diabetes Res Clin Pract 2015; 108: 201-209. doi: 10.1016/j.diabres.2015.01.036.

Kurchenko AI, Komisarenko YI. Imunologia ta alergologiya: nauka I praktyka 2013; 3: 86-91.

Komisarenko YI, Antonenko OV. Endocrinologiya 2012; 17(2): 40-43.

Pludowski P, Grant WB, Bhattoa HP, et al. Int J Endocrinol 2014; 2014: 589587. doi:

Pludowski P, Konstantynowicz J, Jaworski M, et al. Stand Med Pediatr 2014; 11: 609-617.

Braegger C, Campoy C, Colomb V, et al. J Pediatr Gastroenterol Nutr 2013; 56: 692-701. doi:


Andersen R, Molgaard C, Skovgaard LT, et al. Eur J Clin Nutr 2005; 59: 533-541. doi:

Gonzalez-Gross M, Valtuena J, Breidenassel C, et al. Br J Nutr 2012; 107: 755-764. doi:

Holick MF, Binkley N, Bischoff-Ferrari H, et al. J Clin Endocrinol Metab 2011; 96: 1911-1930. doi: 10.1210/ jc.2011-0385

Pludowski P, Karczmarewicz E, Bayer M, et al. Endokrynol Pol 2013; 64: 319-323. doi:

Sung Su Jung. Ann Pediatr Endocrinol Metab 2014; 19(1): 13-19. doi:

Gale EA, Gillespie KM. Diabetologia 2001; 44(1): 3-15. doi:

Dinesh G, Dona P, Girvan B, et al. BMC Res Notes. 2017; 10: 465-468. doi:




How to Cite

Biliaieva, K. S., Vlasenko, M., & Pashkovska, N. (2021). VITAMIN D STATUS IN ADOLSECENTS WITH TYPE 1 DIABETES MELLITUS. Problems of Endocrine Pathology, 72(2), 16-24.