THE DISTURBANCE OF OXIDATION-REDUCTION HOMEOSTASIS IN THE HEART MITOCHONDRIA OF DIABETIC RAT WITH ESTROGEN DEFICIENCY

Authors

DOI:

https://doi.org/10.21856/j-PEP.2015.3.13

Keywords:

diabetes, estrogen deficiency, heart mitochondria, oxidative stress

Abstract

It was investigated the role of estrogen deficiency, type 2 diabetes and their combination in oxidation-reduction homeostasis of the heart mitochondria in experimental rats. It was established that estrogen deficiency and type 2 diabetes leads to oxidative stress in the mitochondria of cardiomyocytes increasing the reactive oxygen species production and reducing the activity of antioxidant enzymes — superoxide dismutase and glutathione, wherein the diabetic condition inhibits the mitochondrial antioxidant system of the heart more than estrogen deficiency. The combination of type 2 diabetes with estrogen deficiency causes additive stimulatory effect on reactive oxygen species production, however, does not increase the negative effects of diabetes on the antioxidant defense system in the heart mitochondria.

References

Rivellese AA, Riccardi G, Vaccaro O. Nutr Metab Cardiovasc Dis 2010; 20(6):474-480.

Leosdottir M, Willenheimer R, Persson M, Nilsson PM. Cardiovasc Diabetol 2011; 10:118.

Alka M, Kanaya M, Grady D, Barrett-Connor E. Arch Intern Med 2002; 162(15):1737-1745.

Sack MN. Mol Cell Cardiol 2009; 46(6):842-849.

Duckles SP, Krause DN, Stirone C, Procaccio V. Mol Interv 2006; 6(1):26-35.

Stirone C, Duckles SP, Krause DN, Procaccio V. Mol Pharmacol 2005; 68(4):959-965.

Zapadnjuk IP, Zapadnjuk VJu, Zaharija EA. Laboratornye zhivotnye, ih razvedenie, soderzhanie i ispol’zovanie v jeksperimente, Kiev, 1962: 253 p.

Lin S, Yang J, Wu G, et al. J Biomed Sci 2010; 17(1):46-56.

Akinmokun A, et al. Diabet Med 1992; 9(4.):432-437.

Chans B. Reguljacija kletochnogo obmena, Moskva, 1962: 111 p.

Lowry O, Rosenbrought N, Farr A. J Biol Chem 1951; 193(1):265-270.

Arutjunjan AV, Dubinina EE, Zybina NN. Metody ocenki svobodnoradikal’nogo okislenija i antioksidantnoj sistemy organizma: metod. rekomendacii, Sankt-Peterburg, 2000: 104 p.

Glans S. Mediko-biologicheskaja statistika, Moskva, 1998: 459 p.

Sena LA, Chandel NS. Mol Cell 2012; 48(2):158-167.

Hulsmans M, Dooren EV, Holvoet P. Curr Atheroscler Rep 2012; 14(3):264-276.

Mattingly KA, Ivanova MM, Riggs KA, et al. Mol Endocrinol 2008; 22(3):609-622.

Scarpulla RCJ. Cell Biochem 2006; 97(4):673-683.

Strehlow K, Rotter S, Wassmann S, et al. Circ Res 2003; 93(2):170-177.

Dubey RK, Jakson EK. Am J Physiol Renal Physiol 2001; 280:F365-F388.

Boudina S, Abel ED. Circulation 2007; 115(25):3213-3223.

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Published

2015-08-22

How to Cite

Gorbenko, N., Borikov, O., Ivanova, O., Kiprich, T., & Taran, K. . (2015). THE DISTURBANCE OF OXIDATION-REDUCTION HOMEOSTASIS IN THE HEART MITOCHONDRIA OF DIABETIC RAT WITH ESTROGEN DEFICIENCY. Problems of Endocrine Pathology, 53(3), 101-106. https://doi.org/10.21856/j-PEP.2015.3.13

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