BIOCHEMICAL MARKERS OF VASCULAR DISFUNCTION INDUCED BY TYPE 2 DIABETES IN FEMALE RATS WITH NORMO- OR HYPOESTROGENIC STATE

Authors

DOI:

https://doi.org/10.21856/j-PEP.2015.3.12

Keywords:

type 2 diabetes, estrogens, vascular dysfunction, nitric oxide synthase, heme oxygenase.

Abstract

The effect of estrogen deficiency on the biochemical parameters of vascular dysfunction induced by type 2 diabetes in female rats was investigated. It was shown that hypoestrogenic state in combination with diabetes promotes more expressive manifestation of insulin resistance and enhances oxidative stress in the blood serum. However, estrogens level does not influence on the hyperglycemia development and changes in activity of nitric oxide synthase and heme oxygenase in the vessels of diabetic animals.

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Published

2015-08-22

How to Cite

Borikov, O., Gorbenko, N., Ivanova, O., Kiprich, T., Taran, K. V. ., & Trzhetsynskyi, S. D. . (2015). BIOCHEMICAL MARKERS OF VASCULAR DISFUNCTION INDUCED BY TYPE 2 DIABETES IN FEMALE RATS WITH NORMO- OR HYPOESTROGENIC STATE. Problems of Endocrine Pathology, 53(3), 94-100. https://doi.org/10.21856/j-PEP.2015.3.12

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