GALSTONE DESEASE — A RISK FACTOR SPECIFIC TYPE OF DIABETES
Keywords:hormones gastrointestinal tract, incretins, diabetes, ghrelin, metabolic syndrome, C-peptide, gallstone disease.
It was analyzed gallstone disease (GSD) as a risk factor for specific form diabetes, to study features of the pathogenesis and course of this form of diabetes, to outline the principles of treatment of disorders of carbohydrate metabolism and diabetes in patients with cholelithiasis. Carbohydrate metabolism was evaluated in 111 patients of cholelithiasis; comparison group 23 people with metabolic syndrome (MS). In patients with MS was found hyperC-peptidemiya. In patients with cholelithiasis levels of C-peptid were normal with a tendency to lower limit of normal, especially when patients were not surgical treated calculous cholecystitis many years. Hyperinsulinism and insulin resistance in the GSD is not found. Gallstone disease patients are at risk for a specific form of diabetes. The pathogenesis of specific form of diabetes is a violation of secretion of incretins gastrointestinal tract. Clinically this form of diabetes resembles type 2 diabetes, but it is fundamentally different of type 2 diabetes by the absence of insulin resistance and hyperinsulinism. The use of GPP-1 and the iDPP-4 is the most suitable method for treating diabetes in the gallstone disease.
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