SINGLE NUCLEOTIDE POLYMORPHISM –308 G/A OF TUMOR NECROSIS FACTOR-ALPHA (TNF) GENE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASESE

Authors

  • Tyzhnenko T. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy
  • Cherniaieva A. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Karachentsev Y. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine; Kharkiv Postgraduate Medical Academy
  • Atramentova L. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Leshchenko Zh. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Gladkih A. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Krasova N. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Pochernyayev A. K. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Opaleiko Y. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Plohotnichenko O. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Chernyavskaya I. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Poltorak V. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2015.4.06

Keywords:

single nucleotide polymorphism, tumor necrosis factor-alpha gene, type 2 diabetes, nonalcoholic fatty liver disease

Abstract

Single nucleotide polymorphism in the promoter region –308 G/A of tumor necrosis factoralpha gene (TNF) in type 2 diabetes mellitus patients (n = 118) and healthy habitants of Kharkiv (n = 50) was studied. There were no significant differences in allele frequencies for single nucleotide polymorphism –308 G/A in patients with type 2 diabetes (pG = 0.861, qA = 0.157), patients with type 2 diabetes in the presence of fatty liver disease (pG = 0.873, qA = 0.127) and healthy individuals (pG = 0.930, qA = 0.070). According to our data the contribution of genetic components in the predisposition to the formation of non-alcoholic fatty liver disease in individuals with diabetes on single nucleotide polymorphism –308 G/A TNF gene was not identified. The obtained data have proved promising for further research, which should be based on a study of the role other candidate genes in the development of nonalcoholic fatty liver disease and their relationship to various metabolic parameters, which will clarify the role of genes in the formation of disease.

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Published

2015-12-03

How to Cite

Tyzhnenko, T. V., Gorshunska, M. Y., Cherniaieva, A. A., Kravchun, N. O., Karachentsev, Y. I., Atramentova, L. O., Leshchenko, Z. A., Gladkih, A. I., Krasova, N. S., Pochernyayev, A. K., Opaleiko, Y. A., Plohotnichenko, O. O., Chernyavskaya, I. V., & Poltorak, V. V. (2015). SINGLE NUCLEOTIDE POLYMORPHISM –308 G/A OF TUMOR NECROSIS FACTOR-ALPHA (TNF) GENE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASESE. Problems of Endocrine Pathology, 54(4), 44-52. https://doi.org/10.21856/j-PEP.2015.4.06

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Section

CLINICAL ENDOCRINOLOGY

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