CLASS G AUTOANTIBODIES TO OXIDATIVELY MODIFIED LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES MELLITUS PATIENTS WHO HAVE HAD NON-Q-MYOCARDIAL INFARCTION

Authors

  • Altunina N. V. A. A. Bohomolets National Medical University, Kyiv
  • Lizogub V. G. A. A. Bohomolets National Medical University, Kyiv
  • Bondarchuk O. N. A. A. Bohomolets National Medical University, Kyiv

DOI:

https://doi.org/10.21856/j-PEP.2015.3.01

Keywords:

type 2 diabetes mellitus, myocardial infarction, autoantibodies to oxidized lowdensity lipoprotein

Abstract

The article presents the results of a study of class G autoantibodies to oxidatively modified low-density lipoprotein (ox-LDL) in patients with type 2 diabetes mellitus which have had non-Qmyocardial infarction and their connection with disturbances of carbohydrate and lipid metabolism, the levels of cytokines. It was identified the decrease level of IgG to ox-LDL in the serum of these patients compared with the control group and patients without diabetes. The study found that with increasing degree of insulin resistance, the concentration of class G autoantibodies to ox-LDL in diabetic postinfarction patients was reduced. It was also revealed their direct connection with the level of anti-inflammatory IL-10. The data obtained may be evidence of the negative impact of carbohydrate metabolism disorders on the level of IgG autoantibodies to ox-LDL and the data may refer to their protective role in type 2 diabetes mellitus with concomitant atherosclerosis.  

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Published

2021-08-17

How to Cite

Altunina, N. V. ., Lizogub, V. G. ., & Bondarchuk, O. N. (2021). CLASS G AUTOANTIBODIES TO OXIDATIVELY MODIFIED LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES MELLITUS PATIENTS WHO HAVE HAD NON-Q-MYOCARDIAL INFARCTION. Problems of Endocrine Pathology, 53(3), 7-14. https://doi.org/10.21856/j-PEP.2015.3.01

Issue

Section

CLINICAL ENDOCRINOLOGY