THE IMPACT OF TREATMENT WITH GLIMEPIRIDE CONTENT OF CERTAIN ADIPOSE TISSUE HORMONES AND CYTOKINES IN PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES

Authors

  • Urbanovych A. M. Danylo Galótsky Lviv National Medical University, Lviv

DOI:

https://doi.org/10.21856/j-PEP.2016.4.05

Keywords:

type 2 diabetes, leptin, resistin, TNF-α, IL-6, IL-2, glimepiride

Abstract

The aim of the research was to study the effect of the drug glimepiride on adipose tissue hormones levels (leptin, resistin) and cytokines (IL-2, IL-6, TNF-α) in type 2 diabetes. 28 patients with newly diagnosed type 2 diabetes were examined before and after 12 months of hypoglycemic glimepiride monotherapy. The results indicate that the normalization of carbohydrate metabolism, cytokines levels after the treatment is caused not only by the direct influence of glimepiride in β-cells of the pancreas, but also by its ability to modulate the secretion of proinflammatory cytokines.

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Published

2021-06-24

How to Cite

Urbanovych, A. M. (2021). THE IMPACT OF TREATMENT WITH GLIMEPIRIDE CONTENT OF CERTAIN ADIPOSE TISSUE HORMONES AND CYTOKINES IN PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES . Problems of Endocrine Pathology, 58(4), 36-41. https://doi.org/10.21856/j-PEP.2016.4.05

Issue

Section

CLINICAL ENDOCRINOLOGY