CERULOPLASMIN LEVEL AND ITS RELATIONSHIP WITH METABOLIC PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES CONCURRENT WITH NONALCOHOLIC FATTY LIVER DISEASE

Authors

  • Zemlyanitsyna O. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2015.4.03

Keywords:

ceruloplasmin, type 2 diabetes, non-alcoholic fatty liver disease, autoimmune thyroiditis

Abstract

A determination of serum ceruloplasmin and its relationship with metabolic parameters in 71 patients with type 2 diabetes mellitus in combination with non-alcoholic fatty liver disease with comorbid autoimmune thyroiditis (group 1, 53 patients) or without (group 2, 18 patients) was concucted. It was revealed an increase of serum ceruloplasmin in 20.8 % of 1st group patients and 27.8 % of 2nd group patients that is regarded as a manifestation of hypoxia of hepatocytes, reduced reactivity of the antioxidant system. A direct correlation of serum ceruloplasmin with indicators of inflammation of the liver tissue, the development of obesity and hypertriglyceridemia in patients of group 1 and adipokine resistin levels in patients 2 groups was found. These regularities require further study.

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Published

2015-12-03

How to Cite

Zemlyanitsyna, O. V. (2015). CERULOPLASMIN LEVEL AND ITS RELATIONSHIP WITH METABOLIC PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES CONCURRENT WITH NONALCOHOLIC FATTY LIVER DISEASE. Problems of Endocrine Pathology, 54(4), 22-28. https://doi.org/10.21856/j-PEP.2015.4.03

Issue

Section

CLINICAL ENDOCRINOLOGY