Thyroid gland reaction on the action of dosed normobaric hypoxia in spontaneously-hypertensive rats in autumn

Authors

  • Yanko R. V. Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv
  • Berezovsky V. Y. Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv
  • Zhernoklov U. O. Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv
  • Litovka I. G. Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv

DOI:

https://doi.org/10.21856/j-PEP.2017.1.09

Keywords:

thyroid gland, normobaric hypoxic gas mixture, spontaneously-hypertensive rats, connective tissue

Abstract

It was investigated the effect of dosed normobaric hypoxia (12% oxygen in nitrogen) in intermittent mode (15 min deoxygenation / 15 min reoxygenation during 2 hours) on thyroid function of young spontaneously hypertensive rats (line SHR) in autumn. It was registered that after 28-day exposure to dosed normobaric hypoxia, thyroid gland activity in SHR rats reduced. This is evidenced by the growth of follicles’ area, colloid, internal follicles’ diameter, colloid accumulation index, decrease of follicular colloid-index and thyroxine concentrations in serum. The width of interlobar, interlobular and interfollicular connective tissue in the gland of experimental animals reduced.

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Published

2021-08-18

How to Cite

Yanko, R. V., Berezovsky, V. Y., Zhernoklov, U. O., & Litovka, I. G. (2021). Thyroid gland reaction on the action of dosed normobaric hypoxia in spontaneously-hypertensive rats in autumn . Problems of Endocrine Pathology, 59(1), 80-86. https://doi.org/10.21856/j-PEP.2017.1.09