The impact of exogenous estrogens on biochemical markers of endothelial dysfunction in diabetic rats with hypoestrogenia

Authors

DOI:

https://doi.org/10.21856/j-PEP.2017.1.05

Keywords:

type 2 diabetes, estrogen deficiency, endothelial dysfunction, estradiol derivative

Abstract

It was investigated the impact of selective estrogen receptor modulator PE0607 comparing to 17β-estradiol on the biochemical markers of endothelial dysfunction in ovariectomized rats with type 2 diabetes. It was established that injection of PE0607 as well as 17β-estradiol decreases lipid peroxidation first products in serum and increases serum whole antioxidant activity and NO-synthase activity in vessels of experimental rats. These results justify the perspectives of compound PE0607 use as a potential gender-specific agent for prevention and treatment of diabetic cardiovascular disorders in women with hypoestrogenia.

References

Sena CM, Pereira AM, Seia R. Biochim Biophys Acta 2013; 1832(12):2216-2231. https://doi.org/10.1016/j.bbadis.2013.08.006

Miller VM, Duckles SP. Pharmacol Rev 2008; 60(2):210-241. https://doi.org/10.1124/pr.107.08002

Kappert K, Bohm M, Schmieder R, et al. Circulation 2012; 126(8):934-941. https://doi.org/10.1161/CIRCULATIONAHA.111.086660

Rivellese AA, Riccardi G, Vaccaro O. Nutr Metab Cardiovasc Dis 2010; 20(6):474-480. https://doi.org/10.1016/j.numecd.2010.01.008

Ferrara A, Quesenberry CP, Karter AJ, et al. Circulation 2003; 107(1):43-48. https://doi.org/10.1161/01.CIR.0000042701.17528.95

Newton KM, Lacroix AZ, Heckbert SR, et al. Diabetes Care 2003; 26(10):2810-2816. https://doi.org/10.2337/diacare.26.10.2810

Gorbenko NI, Taran KV, Jaremenko FG. Liky — ljudyni: materialy 27-i’ nauk.-prakt. konf. z mizhnar. uchastju, Harkiv, 2010: 32-33.

Taran KV, Gorbenko NI, Ivanova OV, Jaremenko FG. Probl Endokryn Patologii’ 2011; 1:32-39.

Gorbenko NI, Taran KV, Ivanova OV, et al. Mate-rialy VII nac. z’i’zdu farmacevtiv Ukrai’ny, Harkiv, 2010:32.

Patent 96493 Sposib modeljuvannja cukrovogo dia-betu 2 typu za umov deficytu estrogeniv.

Arutjunjan AV, Dubinina EE, Zybina NN. Metody ocenki svobodnoradikal’nogo okislenija i antioksi-dantnoj sistemy organizma: Metod. Rekomendacii, Sankt-Peterburg, 2000: 104 p.

Nowell S, Leakey J, Warren J, et al. J Biol Chem 1998; 273(50):33342-33346. https://doi.org/10.1074/jbc.273.50.33342

Berger V, Gelger R, Hess J, et al. Amer J Respir Crit Care Med 2001; 163(6):1493-1499. https://doi.org/10.1164/ajrccm.163.6.9908137

Glans S. Mediko-biologicheskaja statistika, Moskva, 1998: 459 p.

Keating ST, El-Osta A. J Cardiovasc Transl Res 2012; 5(4):399-412. https://doi.org/10.1007/s12265-012-9380-9

Gorbenko NI. 100 izbrannyh lekcij po jendokri-nologii, Har’kov, 2009: 600-606.

Lyle AN, Griendling KK. Physiology (Bethesda) 2006; 21:269-280. https://doi.org/10.1152/physiol.00004.2006

Pacher P, Beckman JS, Liaudet L. Physiol Rev 2007; 87(1):315-424. https://doi.org/10.1152/physrev.00029.2006

Ndisang JF. Mediators Inflamm 2010; 2010: https://doi.org/10.1155/2010/359732.

Wang CY, Chau LY. Chang Gung Med J 2010; 33(1):13-23.

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Published

2017-02-20

How to Cite

Kiprich, T., Gorbenko, N., Borikov, O., Ivanova, O., & Taran, K. V. (2017). The impact of exogenous estrogens on biochemical markers of endothelial dysfunction in diabetic rats with hypoestrogenia. Problems of Endocrine Pathology, 59(1), 46-52. https://doi.org/10.21856/j-PEP.2017.1.05

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