Gonadotoxicity of gadolinium ortovanadate nanoparticles under their chronic exposure
DOI:
https://doi.org/10.21856/j-PEP.2017.3.11Keywords:
gonadotoxicity, nanoparticles, gadolinium orthovanadate, male rats, sperm parametersAbstract
Gonadotoxicity of gadolinium orthovanadate nanoparticles (GdVO4) for intact male rats under chronic exposure of the compound was studied. Toxic effect on the organs of the reproductive system, level of testosterone and biochemical indicators was not detected. Negative changes in the percentage of pathological forms of spermatozoa at 30-day intake of nanoparticles and more pronounced changes in the quality of the spermogram in a dose-dependent manner at the long-term admission period of nanoparticles were found. The chronic exposure of nanoparticles of GdVO4 in potentially therapeutic dose leads to increase in the relative mass of hypophyses and their gonadotrophic activity.
References
Povoroznjuk MV. Med Aspekty Zdorov’ja Muzhchiny 2012; 3(5):62-67.
Ivakhnenko OL, Strilets OP, Kabachny GI. Zaporozhskiy Med Zhurn 2010; 12(2):65-69.
Chekman IS. Fiziol Zhurn 2015; 61(6):129-137. https://doi.org/10.15407/fz61.06.129
Li WQ, Wang F, Liu ZM, et al. Small 2013; 9(9-10):1708-1714. https://doi.org/10.1002/smll.201201702
Rezvanfar МA, Rezvanfar MA, Shahverdi AR, et al. Toxicol Appl Pharmacol 2013; 266(3):356-365.
Kobyliak NM, Falalyeyeva TM, Kuryk OG, et al. EPMA J 2015; 6(1):12. https://doi.org/10.1186/s13167-015-0034-2
Spivak NJa, Nosenko ND, Zholobak NM, et al. Nanosistemy: Fizika, Himija, Matematika 2013; 1(4):72-77.
Afifi M, Almaghrabi OA, Kadasa NM. BioMed Res Int 2015; 2015:1-7.
Karpenko NA, Malukin YuV, Koreneva EM, et al. Proceedings of the International Conference Nanomaterials: Applications and Properties. 3-rd International Conference Nanomaterials, Alushta, 2013; 2(4):04NABM28-1-04NABM28-4.
Belkina IO, Smolenko NP, Klochkov VK, et al. Fiziol Zhurn 2016; 62(5):76-82. https://doi.org/10.15407/fz62.05.076
Garcia TX, Costa GM, Franca LR, Hofmann MC. Reprod Toxicol 2014; 45:59-70. https://doi.org/10.1016/j.reprotox.2014.01.006
Orazizadeh M, Khorsandi L, Absalan F, et al. J Assisted Reprod Genet 2014; 31(5):561-568. https://doi.org/10.1007/s10815-014-0184-5
Doklinichni doslidzhennja likars’kyh zasobiv: metodychni rekomendacii’, za red. OV. Stefanova, Kyi’v, 2001: 678 p.
Dohle GR, Smit M, Weber RFA. World J Urol 2003; 21(5):341-345. https://doi.org/10.1007/s00345-003-0365-9
Litvak EO, Gracheva OO. Med Aspekty Zdorov’ja Muzhchiny 2011; 3:38-44.
Zhang XW, Zhang C, Zhang W, et al. Asian J Androl 2016; 18(5):791-797. https://doi.org/10.4103/1008-682X.167721
Mohammadi Fartkhooni F, Noori A, Momayez M, et al. Euro J Exp Bio andrology 2013; 3(4):145-149.
Miresmaili SM, Pourentezari M, Amraii E, et al. Iranian J Reprod Med Androl 2014; 12(2):139-144.
Li B, Fan H, Zhao Q, Wang C. Materials 2016; 9(3):149. https://doi.org/10.3390/ma9030132
Kang X, Yang D, Ma PA, et al. Langmuir 2013; 29(4):1286-1294. https://doi.org/10.1021/la304556w
ISSN 
ISSN 
