Gonadotoxicity of gadolinium ortovanadate nanoparticles under their chronic exposure

Authors

  • Belkina I. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2017.3.11

Keywords:

gonadotoxicity, nanoparticles, gadolinium orthovanadate, male rats, sperm parameters

Abstract

Gonadotoxicity of gadolinium orthovanadate nanoparticles (GdVO4) for intact male rats under chronic exposure of the compound was studied. Toxic effect on the organs of the reproductive system, level of testosterone and biochemical indicators was not detected. Negative changes in the percentage of pathological forms of spermatozoa at 30-day intake of nanoparticles and more pronounced changes in the quality of the spermogram in a dose-dependent manner at the long-term admission period of nanoparticles were found. The chronic exposure of nanoparticles of GdVO4 in potentially therapeutic dose leads to increase in the relative mass of hypophyses and their gonadotrophic activity.

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Published

2021-06-24

How to Cite

Belkina, I. O. (2021). Gonadotoxicity of gadolinium ortovanadate nanoparticles under their chronic exposure. Problems of Endocrine Pathology, 61(3), 78-85. https://doi.org/10.21856/j-PEP.2017.3.11