ADIPOKINES DISBAL ANCE IN ESSENTIAL HYPERTENSION AND CONCOMITANT T YPE 2 DIABETES DEPENDING ON GENETIC POLYMORPHISM OF AGTR1 GENE

Authors

  • Bilovol O. M. Kharkiv National Medical University, Kharkiv, Ukraine
  • Bobronnikova L. R. Kharkiv National Medical University, Kharkiv, Ukraine
  • Shalimovа A. S. Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2017.2.02

Keywords:

: essential hypertension, type 2 diabetes, adipokines disbalance, genetic polymorphism

Abstract

The aim of the study was assessed the levels of adipokines (leptin and adiponectin) in patients with comorbidity of essential hypertension (EH) and type 2 diabetes (DM2) depending on A1166C polymorphism of AGTR1
gene. There were examined 320 patients with EH stage II, grade 2 and type 2 diabetes moderate, subcompensated; 90 patients with EH stage II, grade 2 without type 2 diabetes and 31 healthy individuals. It was found
that genetic polymorphism of AGTR1 gene is associated with the development of comorbidity of EH and DM2.
A1166C gene polymorphism of AGTR1 affects the severity of carbohydrate disorders in EH as the presence and
absence of DM2, and is associated with the difference of adipokines levels only in comorbidity of EH and DM2.

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Published

2021-08-18

How to Cite

Bilovol, O. M., Bobronnikova, L. R., & Shalimovа A. S. (2021). ADIPOKINES DISBAL ANCE IN ESSENTIAL HYPERTENSION AND CONCOMITANT T YPE 2 DIABETES DEPENDING ON GENETIC POLYMORPHISM OF AGTR1 GENE. Problems of Endocrine Pathology, 60(2), 13-19. https://doi.org/10.21856/j-PEP.2017.2.02

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Section

CLINICAL ENDOCRINOLOGY