Influence of dosed normobaric hypoxia and melatonin on the morphofunctional state of the thyroid gland
DOI:
https://doi.org/10.21856/j-PEP.2018.1.09Keywords:
thyroid gland, hypoxia, melatoninAbstract
It was investigated the combined effects of dosed normobaric hypoxia and melatonin on the morphofunctional state of the thyroid gland. The experimental animals were daily given a hypoxic gas mixture (12 % O2) in intermittent mode: 15 min deoxygenation/15 min reoxygenation during 2 hours and orally administered melatonin at 10.00 at a dose of 5 mg/kg body weight. The total duration of the experiment was 28 days. It was registered that in the thyroid gland of the experimental rats, a decrease of follicles' area, colloid, internal follicles' diameter, colloid accumulation index and increase in the height of the thyrocytes, a follicular-colloid index and thyroxine concentrations in serum. The width of interlobar, interlobular and interfollicular connective tissue in the gland of experimental animals reduced.
References
Vasil'eva EV, Tararak TYa, Vasil'eva NA, et al. Vestnik TvGU. Seriya: Biologiya i ekologiya 2008; 8: 8-13.
Sawhney RC, Malhotra AS. Int J Biometeorol. 1990;4(3): 161-163. doi: http://doi.org/10.1007/BF01048714
Berezovskiy VA. Prirodnaya i instrumental'naya oroterapiya, Donetsk, 2012: 304 р.
Dawson D, van den Heuvel CJ. Ann Med 1998; 30(1): 95-102. doi: http://doi.org/10.3109/07853899808999390
Lewinski A, Karbownik M. Neuro Endocrinol Lett. 2002; 23(1): 73-78.
Ma Y, Freitag P, Zhou J, et al. Am J Physiol Regul Integr Comp Physiol 2004; 287(3): 600-607. doi: http://doi.org/10.1152/ajpregu.00115.2004
Yang YJ, Na HJ, Suh MJ, et al. Yonsei Med J 2015;56(6): 1503-1514. doi: http://doi.org/10.3349/ymj.2015.56.6.1503.
Yang Y, Lu Y, Chen T, et al. Int J Dev Biol 2016; 60(4-6): 85-93. doi: http://doi.org/10.1387/ijdb.160083yy.
Baltaci AK, Mogulkoc R, Kul A, et al. Toxicology 2004;195(1): 69-75. doi: http://doi.org/10.1016/j.tox.2003.09.001
Champney TH. Gen Comp Endocrinol 2001; 123(2): 121-126. doi: http://doi.org/10.1006/gcen.2001.7665
Prakash P, Laloraya M, Kumar P. Biochem Mol Biol Int 1998; 46(6): 1249-1258.
Korzhevskiy D, Gilyarov A. Osnovy gistologicheskoy tekhniki, Sankt-Peterburg, 2010: 95 р.
Nikishin DV. Morfologiya i metody issledovaniya shchitovidnoy zhelezy: Metodicheskie rekomendatsii, Penza, 2008: 64 р.
Yanko RV. Endokrynologija 2016; 21(1): 33-37.
Yanko RV. Fiziol Zhurn 2015;61(5): 46-51. doi.: http://doi.org/10.15407/fz61.05.046
Zhernoklov U, Berezovskyi V, Litovka I. Eur J Tech Nat Sci 2016;4: 3-8. doi: http://doi.org/10.20534/EJTNS-16-4-3-8.
Kalyuzhnaya LI. Endokrinnye mekhanizmy adaptatsii organizma k usloviyam vysokogor'ya. Gipoksiya. Adaptatsiya. Patogenez. Klinika 2000: 235-265.
Panda JN, Turner CW, Powell М. Acta Endocrinol 1968;57(1): 363-373.
Dzerzhynsky ME, Gorelikova OI, Pustovalov AS. J Reprod Biol Health 2006; 6(2): 79-85.
Bondarenko LA, Sotnik NN, Chagovets EM, et al. Bull Exp Biol Med 2011; 150(6): 753-755. doi: http://doi.org/10.1007/s10517-011-1241-z