Influence of dosed normobaric hypoxia and melatonin on the morphofunctional state of the thyroid gland
DOI:
https://doi.org/10.21856/j-PEP.2018.1.09Keywords:
thyroid gland, hypoxia, melatoninAbstract
It was investigated the combined effects of dosed normobaric hypoxia and melatonin on the morphofunctional state of the thyroid gland. The experimental animals were daily given a hypoxic gas mixture (12 % O2) in intermittent mode: 15 min deoxygenation/15 min reoxygenation during 2 hours and orally administered melatonin at 10.00 at a dose of 5 mg/kg body weight. The total duration of the experiment was 28 days. It was registered that in the thyroid gland of the experimental rats, a decrease of follicles' area, colloid, internal follicles' diameter, colloid accumulation index and increase in the height of the thyrocytes, a follicular-colloid index and thyroxine concentrations in serum. The width of interlobar, interlobular and interfollicular connective tissue in the gland of experimental animals reduced.
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