THE IMPACT OF DIABETES MELLITUS ON THE FUNCTIONAL STATE OF THE MITOCHONDRIA IN THE HEART OF MALE AND FEMALE RATS

Authors

DOI:

https://doi.org/10.21856/j-PEP.2019.4.15

Keywords:

type 2 diabetes mellitus, cardiomyocytes, mitochondrial permeability transition pore, mitochondria functional state, sex differences

Abstract

Type 2 diabetes is one of the main factors of the cardiovascular risk, which leads to a disproportionate
increase in cardiovascular events in women and men. All causes of increased cardiovascular risk in women with
type 2 diabetes mellitus are not established, one of the most likely causes of cardiac activity is considered to be
gender features of biogenesis and activity of myocardial mitochondria. A comparative analysis of changes in the
functional state of the heart mitochondria in males and females rats with experimental type 2 diabetes mellitus
was conducted. It was established that the activity of succinate dehydrogenase, the part of complex II of the
electron transport chain, reduced more significantly in diabetic males compared with diabetic females. Type 2
diabetes mellitus also caused a greater decrease in the activity of the energy metabolism enzyme — aconitase,
in heart mitochondria of male compared to female. One of the leading mechanisms of cardiomyocytes’ apoptotic
or necrotic death in conditions of mitochondrial dysfunction, in particular induced by diabetes, is the activation
of a nonspecific mitochondrial pore opening (mPTP, mitochondrial permeability transition pore). It was found
a more pronounced activation of mPTP and more significant decrease in thioredoxin reductase activity in
males with type 2 diabetes mellitus compared with diabetic females. The obtained data may indicate a greater
sensitivity of male cardiomyocytes to the damaging effects of proapoptotic factors

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Published

2019-11-11

How to Cite

Gorbenko, N., Borikov, O., Ivanova, O., Kozar, V. V., & Kiprych, T. (2019). THE IMPACT OF DIABETES MELLITUS ON THE FUNCTIONAL STATE OF THE MITOCHONDRIA IN THE HEART OF MALE AND FEMALE RATS. Problems of Endocrine Pathology, 70(4), 110-115. https://doi.org/10.21856/j-PEP.2019.4.15

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