CURRENT IDE A OF PANCREATOGENIC DIABETES

Authors

  • Zhuravlyova L. V. Kharkiv National Medical University, Kharkiv, Ukraine
  • Zhuravlyova A. K. Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.2.15

Keywords:

pancreatogenic diabetes, type 3c diabetes, chronic pancreatitis, exocrine insufficiency of pancreas.

Abstract

This article is a review of current literature covering issues of terminology, classification, prevalence, pathogenesis, clinical manifestations, diagnosis and treatment of diabetes associated with diseases of the exocrine
pancreas. It has been established that the prevalence of type 3c diabetes is much higher than the recorded incidence, which is associated with the difficulties of diagnosis and the absence of specific criteria for making this
diagnosis. The most common cause of diabetes type 3c is chronic pancreatitis. The main defect is insufficient
insulin secretion along with the development of hepatic resistance to it, as well as insufficient postprandial glucose-dependent stimulation of insulin secretion due to a decrease in incretin production. Usually there is compensatory increase in peripheral insulin sensitivity, which can lead to severe cases of hypoglycemia, especially
on the background of insulin therapy, and causes a «brittle» course of this type of diabetes. However, peripheral
insulin resistance may also occur. Clinical manifestations are associated with exocrine insufficiency of pancreas, and are characterized by the presence of malabsorption and malnutrition, an increased risk of osteoporosis
and bone fractures. Currently, there are no guidelines for management of type 3c diabetes, and the main goal is
to achieve HbA1c < 7 % to minimize the risk of complications, as in type 1 and 2 diabetes. Mild hyperglycemia
can be adjusted by taking oral glucose-lowering drugs, severe patients and patients with very low body weight
should receive insulin replacement therapy. Also, the choice of glucose-lowering therapy depends on the primary
disease of the pancreas that caused diabetes

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Published

2021-06-30

How to Cite

Журавльова , Л. В., & Журавлева, А. К. (2021). CURRENT IDE A OF PANCREATOGENIC DIABETES. Problems of Endocrine Pathology, 68(2), 104-111. https://doi.org/10.21856/j-PEP.2019.2.15