STATE OF GLUCOSE HOMEOSTASIS IN WOMEN WITH TYPE 2 DIABETES MELLITUS WITH HYPERURICEMIA
Keywords:type 2 diabetes mellitus, hyperuricemia, glucose homeostasis, insulin resistance
The aim of the study was to determine the frequency of hyperuricemia and to analyze the relationship
between the state of glucose homeostasis and the level of uric acid in the blood of patients with type 2 diabetes
mellitus (type 2 diabetes) in women. Materials and methods. 47 women with type 2 diabetes were examined.
The average age of the examined patients was (62.8 ± 7.8) Me 63.0 [42–81] years. Age at the time of disease
manifestation (45,7 ± 8,9) Me 47,5 [30–76] years. The average duration of the disease is (16.5 ± 9.8) Me 13.0
[2.0–40.0] years. The presence and degree of obesity were determined by body mass index (BMI), according to
the criteria of World Health Organization (2000). Measured waist volume (cm) and hips volume (cm). The index
waist/hip volume was calculated. Venous blood samples for hormonal studies were obtained on an empty stomach. Glucose content in fasting blood plasma and 2 hours after meals was determined by glucose oxidant method
using glucose analyzer «Biosen C-line» (Germany). The level of glycosylated hemoglobin (HbAc1) in the blood
was determined by photocolorimetric method. HOMA2 IR, HOMA2 %B, and HOMA2 %S were calculated using
an improved NOME calculator model. The level of total cholesterol and triglycerides was determined by colorimetric method, high density lipoprotein cholesterol (HDL-cholesterol) — by precipitation in serum. Cholesterol
levels of low-density and very low-density lipoproteins were calculated by using Friedwald formulas. The level of
uric acid in blood serum was examined by colorimetric method. Taking into account the level of uric acid in the
blood, the patients were divided into groups: group 1 (n = 25) — uric acid in the blood within the reference values for women (< 350 µmol/l), 2 (n = 15) — uric acid in the blood above the upper limit of the reference value for
women (> 350 µmol/l). Statistical analysis of the data was carried out with the software package «Statgraphics
Plus for Windows 10». Research result. Hyperuricemia was diagnosed in 43.0 % (n = 40) women with type 2
diabetes. The analysis of the studied clinical and biochemical parameters in the groups was carried out taking
into account the level of uric acid in the blood. By weight, BMI, waist volume and index waist/hip volume the
study groups did not differ significantly. Group 2 of women with hyperuricemia have hyperinsulinemia, which is
indicated by a significantly higher level of IRI and the value of the HOMA2 B % index, and insulin resistance.
It was found that women in group 2 with carbohydrate metabolism disorders associated with index waist/hip
volume and the level of HDL-cholesterol in the blood. At the same time, the effect of index waist/hip volume on
the level of postprandial glycaemia and HbAc1 is more significant than HDL-cholesterol in the corresponding
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