ALGORITHM FOR PREDICTING OF RADIOIODINE RESISTANCE OF THYROID PAPILL ARY CARCINOMA ON THE BASIS OF CY TOLOGICAL STUDY OF THE MATERIAL OF FINE NEEDLE ASPIRATION BIOPSIES

Authors

  • Tron'ko M. D. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine
  • Zelinskaya G. V. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine
  • Kvachenyuk A. M. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine
  • Bozhok Y. M. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine
  • Kulinichenko G. M. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.4.13

Keywords:

thyroid papillary carcinoma, radioiodine-refractory metastases, fine needle aspiration biopsy, cytological prognosis.

Abstract

Radioiodine-resistant metastases are relevant problem in the diagnosis and treatment of differentiated thyroid cancer. The
aim of the work was to perform complex cytological and immunocytochemical studies of the punctates of postoperative metastases of papillary thyroid cancer in order to determine the features of their cells, on the basis of which it is possible to create an
algorithm for preoperative prediction of the effectiveness of radioiodine therapy. Cytological and immunocytochemical studies
were performed on the material of fine needle aspiration biopsies of 110 metastases of papillary thyroid carcinomas detected in
the postoperative period (85 radioiodine resistant and 25 radiosensitive metastases). Statistical data processing was performed
using the non-parametric Mana-Whitney test and the ӽ2
test in Statistica.11. A statistically significant difference was found
at p < 0.001 between radioiodine-refractory and radioiodine-avid metastases in expression of thyroid peroxidase and thyroglobulin as a result of this work, the algorithm of preoperative prediction of radioiodine refractory of the thyroid papillary carcinoma was proposed for the first time on the basis of detection of cytological and immunocytochemical features of thyrocytes
in punctates. Determination of expression of cytokeratin 17 in punctates of primary papillary carcinoma, cytological features
of thyrocytes, expression of thyroid peroxidase and thyroglobulin in postoperative metastases, allow prediction of radioiodine
refractory and determination of adequate therapy in patients with papillary carcinoma.

References

Haugen B, Alexander E, Bible K, et al. Thyroid. 2016; 26: 1-133. doi: http://doi.org/10.1089/thy.2015.0020.

Pacini F, Yasuhiro L, Markus I. Exp Rev Endocrinol Metab. 2012; 7: 541-544. doi: http://doi.org/10.1586/eem.12.36.

Pfister D, Fagin J. Clin Oncol. 2008; 26: 4701-4704. doi: http://doi.org/10.1200/JCO.2008.17.3682.

Busaidy NL. J Thyr Res 2012;2: 11-12. doi: http://doi.org/10.1155/ 2012/618985.

Markovina S, Grigsby P, Schwarz J, et al. Thyroid. 2014; 24: 1121-1126.

Jepshtejn EV, Olejnik VA, Sovenko TK. Promeneva diagnostyka, promeneva terapija. 2000; 1: 53-54.

Worden F. Ther Adv Med Oncol 2014; 6: 267-279. doi: http://doi.org/ 10.1177/1758834014548188.

Chae Moon Hong, Byeong-Cheol Ahn. Front Endocrinol (Lausanne) 2017; 8: 260. doi: http://doi.org/ 10.3389/fendo.2017.00260 .

Yasuhiro Ito, Akira Miyauchi, Mitsuru Ito, et al. Endocrine J 2014; 61(8): 1145.

Shangtong Lei, Zihai Ding, Junna Ge, Donghui Zhao. Oncol Let 2015; 10(3): 1749-1754 p. doi: http://doi.org/ 10.3892/ol.2015. 3416.

Rivera M, Ghossein R, Schoder H, et al. Cancer. 2008; 113(1): 48-56. doi: http://doi.org/10.1002/cncr.23515.

Deandreis D, Ghuzlan A, Leboulleux S, et al. Endocrinol Related Cancer. 2011; 1: 159-169. doi: http://doi.org/ 10.1677/ERC10-0233.

Lastra R, Ricardo R, Lastra M, et al. Cancer Cytopathol. 2014; 122: 484-503. doi: http://doi.org/ 10.1002/cncy.21417.

Min J, Chung J, Lee Y, et al. Eur J Nucl Med. 2001; 28: 639-645.

Xing M, Westra W, Tufano R. J Clin Endocrinol Metab. 2005; 90(12): 6373-6379. doi: http://doi.org/10.1210/jc.2005-0987.

Bozhok Y‚ Tavokina L, Epstein E. Med Ann. 1996; 138: 40-43.

Zelinskaya A. Oncology 2019; 21(1): 31-35.

Downloads

Published

2019-11-11

How to Cite

Tron’ko, M. D., Zelinskaya, G. V., Kvachenyuk, A. M., Bozhok, Y. M., & Kulinichenko, G. M. (2019). ALGORITHM FOR PREDICTING OF RADIOIODINE RESISTANCE OF THYROID PAPILL ARY CARCINOMA ON THE BASIS OF CY TOLOGICAL STUDY OF THE MATERIAL OF FINE NEEDLE ASPIRATION BIOPSIES. Problems of Endocrine Pathology, 70(4), 96-102. https://doi.org/10.21856/j-PEP.2019.4.13

Issue

Section

CLINICAL ENDOCRINOLOGY