Level of urikemia in patients with diabetes mellitus and anthropometric indices: clinical and biochemical correlations

Authors

  • Chernyaeva A. Kharkiv Postgraduate Medical Academy, Kharkiv, Ukraine; SI «V. Danilevsky Institute of Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Mykytyuk M. Kharkiv Postgraduate Medical Academy, Kharkiv, Ukraine
  • Karachentsev Iu. Kharkiv Postgraduate Medical Academy, Kharkiv, Ukraine; SI «V. Danilevsky Institute of Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. SI «V. Danilevsky Institute of Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.2.11

Keywords:

urinary acid, diabetes mellitus, anthropometric indexes.

Abstract

Aim — to study correlations between the level of urinary acid (UA) in blood and anthropometric indexes for patients wih diabetes mellitus (DM) taking into account the type of disease and sex. 79 is studed patients of DM 1 (53 women and 26 men) (group 1) and 159 patients of DM 2 (89 women and 70 men) (group 2). Age of patients in a group 1 was 75 from 19 to, mean — (42.3 ± 12.1) years; in a group 2 — 81 from 34 to, mean — (60.6 ± 9.2) years. Determined anthropometric indexes: body mass index (BMI), waist circumference (WC), index waist circumference/thighs circumference (IWC/TC), index of distribution of fat (IDF), ABSI and index waist/height circumference (IWC/height). The level of UA at blood was investigated by a colorimetery method. A hyperuricemia is diagnosed at 23.5 % of patients in a general group. A hyperuricemia more often DM 2 of sex of (2 : 1) women exposed for the patients of DM. For the patients of DM regardless of type of disease and sex the level of UA in blood was associated with all investigated anthropometric indexes. The level of UA in blood for the patients of DM regardless of type of disease and sex was associated with BMI < 30 kg/м2 (r = – 0,38; Р = 0,003). For the patients of DM 1 and 2 regardless of BMI and with BMI > 30 kg/м2 variableness of level of UA was de­termined by not BMI, and anthropometric indexes (WC, IWC/Height, IDF, ABSI) that give information about the features of distribution of fat, i.e. expressed of abdominal type of obesity. For the patients of DM 1 of sex of men the variableness of level of UA determines BMI, sex of women — BMI and expressed of abdominal type of obesity (OT, ABSI). For the patients of DM 2 of sex of men the level of UA is associated with BMI and IWC/TC and IDF; for women — with WC, IDF and ABSI.

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Published

2021-06-30

How to Cite

Черняєва, А. О., Микитюк, М. Р., Караченцев, Ю. І., & Кравчун Н. O. (2021). Level of urikemia in patients with diabetes mellitus and anthropometric indices: clinical and biochemical correlations. Problems of Endocrine Pathology, 68(2), 73-80. https://doi.org/10.21856/j-PEP.2019.2.11

Issue

Section

CLINICAL ENDOCRINOLOGY

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