CHANGES IN ADIPOCYTOKINES IN PATIENTS WITH ALCOHOLIC CIRRHOSIS OF THE LIVER ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE STAGE OF DECOMPENSATION*

Authors

  • Matkovska M. R. SHEE «Ivano-Frankivsk National Medical University», Ivano-Frankivsk, Ukraine
  • Virstiuk N. H. SHEE «Ivano-Frankivsk National Medical University», Ivano-Frankivsk, Ukraine
  • Balan U. V. SHEE «Ivano-Frankivsk National Medical University», Ivano-Frankivsk, Ukraine; 2 Regional Clinical Hospital, Ivano-Frankivsk, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.4.10

Keywords:

alcoholic liver disease, non-alcoholic fatty liver disease, cirrhosis

Abstract

According to the literature, alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are
two hepatic diseases with similar pathogenetic mechanisms of the development, progression and histological
characteristics. Both ALD and NAFLD are associated with a lipid metabolism disorder and a disorder of the
synthesis of adipokines. Adiponectin, leptin and resistin are the most described adipokines whose role in the
development and progression of diseases accompanied by lipid disorders is ambiguous and is still the subject
of scientific research. The purpose of the research was to study the changes in adipocytokines in patients with
alcoholic liver cirrhosis (ALC) associated with NAFLD depending on the stage of decompensation. The study included 204 patients. Among them, 78 patients (Gr. I) had ALC and 126 patients (Gr. II) had a combination of ALC
with NAFLD. Patients were subgrouped according to compensation classes by the Child-Pugh score (A, B, C).
With the progression of the liver cirrhosis the level of leptin decreased, while the levels of adiponectin and
resistin increased. The higher content of leptin in patients of classes A and B is accompanied not only by the
impaired liver function, but also by its increased release from adipose tissue. In patients of class C fat depot is
exhausted, therefore the level of leptin decreases. Moreover, this decrease correlates with the severity of the
disease and the prognostic MELD score. The level of adiponectin was lowered in class A patients and increased
in patients with more severe course and correlated with severity of the disease and MELD score. The level of
resistin was increased in proportion to the deterioration of the liver function and correlated with the Child-Pugh
score and the MELD score. The revealed correlation between the levels of resistin, leptin and adiponectin with
the degree of severity of the liver cirrhosis and the prognostic MELD score allows considering their changes for
assessment of the severity of the liver cirrhosis and predicting the course of the disease.

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Published

2019-11-11

How to Cite

Matkovska, N. R., Virstiuk, N. H., & Balan, U. V. (2019). CHANGES IN ADIPOCYTOKINES IN PATIENTS WITH ALCOHOLIC CIRRHOSIS OF THE LIVER ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE STAGE OF DECOMPENSATION*. Problems of Endocrine Pathology, 70(4), 75-80. https://doi.org/10.21856/j-PEP.2019.4.10

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Section

CLINICAL ENDOCRINOLOGY