ENDOTHELIN-1 VALUE IN CARDIOVASCULAR COMPLICATIONS DEVELOPMENT FORECASTING IN PATIENTS WITH DIABETES MELITUS TYPE 2 AND CORONARY ARTERY DISEASE*
DOI:
https://doi.org/10.21856/j-PEP.2019.4.08Keywords:
endothelin-1, nitrogen oxide metabolites, diabetes melitus, chronic heart failure, cardiovascular complications, сardiovascular complications riskAbstract
On the basis of 98 patients inspection with chronic heart failure of ischemic genesis and diabetes melitus
type 2 an endothelin-1 influence and cardiovascular complications existence were studied. As a result of the conducted researches it is established that endothelin-1 level in patients with diabetes melitus type 2 and chronic
heart failure is higher, than in patients with chronic heart failure without diabetes melitus type 2. It was
found that blood glucose and glycose hemoglobin levels were significantly higher in patients with FC III than in
patients with FC I and FC II. Due to the fact that the cardiovascular complications risk development stratification concept in patients with diabetes mellitus type 2 and coronary artery disease involves a general strategy
of prevention, treatment and prognosis taking into account personal, medical and social characteristics of the
patient. The developed mathematical model of cardiovascular complications development forecasting has shown
endothelin-1 and nitrogen oxide metabolites value as cardiovascular risk markers
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