PECULIARITIES OF HORMONAL HOMEOSTASIS IN FULL-TERM NEWBORNS FROM MOTHER WITH RECURRENT MISCARRIAGE AND PROVEN DEFICIENCY OF THE LUTEAL PHASE

Authors

  • Kurilina T. V. Shupyk National medical academy of postgraduate education, Kyiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.4.09

Keywords:

newborn infant; recurrent miscarriage; progesterone; hormonal homeostasis.

Abstract

The pattern of the hormonal homeostasis in healthy, full-term newborns from mothers with recurrent miscarriage and proven luteal phase deficiency after treatment of threatened abortion with progestins was investigated.
It has been established that the emergence of threatened abortion significantly activates the compensatoryadaptive mechanisms of the newborn, which is expressed in an increased synthesis of hormones of hypophysis
(GH, TSH, prolactin), the thyroid gland and cortisol in the first days of life with a certain stabilization by the
end of the early neonatal period.
When prescribing medicines with gestagenic activities, changes in hormonal homeostasis are unequal
and depend on their type. The use of oil progesterone intramuscularly practically not reflected on hormonal
homeostasis. The use of micronized progesterone changed the hormonal profile in the first days of life, which
expressed by significantly elevated levels of cortisol and prolactin, as well as reduced GH and TSH with follow
normalization of indices.
The inclusion of dydrogesteron in the complex treatment of a pregnant woman is largely reflected in the
pituitary-thyroid system as changes in the secretion of TSH and the synthesis of iodothyronines are observed
throughout the entire early neonatal period.
Prescribing progestins at the modern stage may contribute to the improvement of reproductive indicators, but requires strict adherence to indications when prescribing gestagens, careful observation of newborns
throughout the neonatal period and young children with the formation of risk groups for possible hormonal and
metabolic disorders.

References

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Published

2019-11-11

How to Cite

Kurilina Т. V. (2019). PECULIARITIES OF HORMONAL HOMEOSTASIS IN FULL-TERM NEWBORNS FROM MOTHER WITH RECURRENT MISCARRIAGE AND PROVEN DEFICIENCY OF THE LUTEAL PHASE. Problems of Endocrine Pathology, 70(4), 67-74. https://doi.org/10.21856/j-PEP.2019.4.09

Issue

Section

CLINICAL ENDOCRINOLOGY