DIABETES MELLITUS AND COGNITIVE DYSFUNCTION. THE ROLE OF METFORMIN IN PATHOGENESIS AND TRE ATMENT OF COGNITIVE DYSFUNCTION (literature review)

Authors

  • Sokolova L. K. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraineof Ukraine», Kiev, Ukraine
  • Pushkarev V. M. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine
  • Pushkarev V. V. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine
  • Kovzun E. I. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine
  • Tronko N. D. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2018.2.10

Keywords:

diabetes mellitus, central nervous system, cognitive dysfunction, Alzheimer’s disease, metformin.

Abstract

In the review, data are presented that indicate the relationship of diabetes and violations of cognitive
abilities of a person. At diabetes serious structural and functional changes in nervous system and its blood vessels are observed. DM accelerates the development of Alzheimer’s disease, stimulating the formation of senile
plaques and neurofibrillary tangles. The key factors in this complication of diabetes are hyper- and hypoglycemia, as well as impaired insulin/IGF signaling. Diabetic patients taking metformin are less susceptible to cognitive impairment. Neuroprotective effects of metformin appear to be related to its hypoglycemic, antioxidant
and anti-apoptotic properties.

References

Saedi E, Gheini MR, Faiz F, Arami MA. World J Diabetes 2016; 7(17): 412-422. doi: http://doi.org/10.4239/wjd.v7.i17.412.

Sridhar GR, Lakshmi G, Nagamani G. World J Diabetes 2015; 6 (5): 744-751.

Koekkoek PS, Rutten GE, Biessels GJ. Handb Clin Neurol 2014; 126: 145-166. doi: http://doi.org/10.1016/B978-0-444-53480-4.00011-4.

Van Bussel FCG, Backes WH, Hofman PAM, et al. Front Neurosci 2017; 11: 188. doi: http://doi.org/10.3389/fnins.2017.00188.

Bornstein NM, Brainin M, Guekht A, et al. Neurol Sci 2014; 35 (7): 995-1001. doi: http://doi.org/10.1007/s10072-014-1797-2.

Wardlaw JM, Smith EE, Biessels GJ, et al. Lancet Neurol 2013; 12: 822-838. doi: http://doi.org/10.1016/S1474-4422(13)70124-8.

Imamine R, Kawamura T, Umemura T, et al. Diabetes Res Clin Pract 2011;94: 91-99. doi: http://doi.org/10.1016/j.diabres. 2011.06.014.

Xia W, Rao H, Spaeth AM, et al. Medicine (Baltimore) 2015a; 94: e2231. doi: http://doi.org/10.1097/MD.0000000000002231.

Jansen JF, Van Bussel FC, Van De Haar HJ, et al. Sci Rep 2016; 6: 10. doi: http://doi.org/10.1038/s41598-016-0003-6.

Cui Y, Jiao Y, Chen YC, et al. Diabetes 2014; 63: 749-760.

Chen Y, Liu Z, Wang A, et al. Psychoneuroendocrinology 2016; 74: 141-148.

Xia W, Wang S, Rao H, et al. Sci Rep 2015b; 5: 11148. doi: http://doi.org/10.1038/srep11148.

Zhang Y, Lu S, Liu C, et al. Sci Rep 2016; 6: 23767. doi: http://doi.org/10.1038/srep23767.

Reijmer YD, Brundel M, De Bresser J, et al. Diabetes Care 2013a; 36: 137-144.

Kimura N. Int J Mol Sci 2016; 17 (4): 503. doi: http://doi.org/10.3390/ ijms17040503.

Armstrong RA. Folia Neuropathol 2009; 47: 289-299.

Sheng ZH. J Cell Biol 2014; 204: 1087-1098.

Kellner Y, Gödecke N, Dierkes T, et al. Front Synaptic Neurosci 2014; 6: 5. doi: http://doi.org/10.3389/fnsyn.2014.00005.

Crane PK, Walker R, Hubbard RA, et al. N Engl J Med 2013; 369: 540-548.

Butterfield DA, Di Domenico F, Barone E. Biochim Biophys Acta 2014; 1842: 1693-1706.

Okabayashi S, Shimozawa N, Yasutomi Y, et al. PLoS ONE 2015; 10: e0117362.

Mehla J, Chauhan BC, Chauhan NB. J Alzheimers Dis 2014; 39: 145-162.

Lin F, Jia J, Qin W. Neuroreport 2014; 25: 1289-1295.

Nagai N, Ito Y, Tanino T. Biol Pharm Bull 2015;38: 601-610.

Takeda S, Sato N, Uchio-Yamada K, et al. PNAS 2010; 107: 7036-7041.

De la Monte SM. Endocrinol Metab Clin North Am 2014; 43: 245-267.

Li J, Deng J, Sheng W, Zuo Z. Pharmacol Biochem Behav 2012; 101 (4): 564-574.

Tron'ko ND, Kovzun EI, Pushkarev VM. Zhurnal NAMN Ukrai'ny 2012; 4: 430-437.

Plaschke K, Kopitz J, Siegelin M, et al. J Alzheimers Dis 2010; 19: 691-704.

Papon MA, El Khoury NB, Marcouiller F, et a. Diabetes 2013; 62: 609-617.

Pedrós I, Petrov D, Allgaier M, et al. Biochim Biophys Acta 2014; 1842: 1556-1566.

Claxton A, Baker LD, Hanson A, et al. J Alzheimers Dis 2015; 44: 897-906.

Kawamura T, Umemura T, Hotta N. J Diabetes Investig 2012; 3: 413-423.

Palleria C, Leporini C, Maida F, et al. Front Neuroendocrinol 2016; 42: 76-92.

Trevino S, Aguilar-Alonso P, Flores Hernandez JA, et al. Synapse 2015; 69: 421-433.

Morales-Corraliza J, Wong H, Mazzella MJ, et al. J Neurosci 2016; 36: 4248-4258.

Nazaribadie M, Amini M, Ahmadpanah M, et al. J Diabetes Metab Disord 2014; 13: 27. doi: http://doi.org/10.1186/2251-6581-13-27.

Oliveira WH, Nunes AK, França ME, et al. Brain Res 2016; 1644: 149-160.

Niiya Y, Abumiya T, Yamagishi S, et al. J Stroke Cerebrovasc Dis 2012; 21: 293-298.

Nagayach A, Patro N, Patro I. Metab Brain Dis 2014; 29 (3): 747-761.

Arnold SE, Lucki I, Brookshire BR, et al. Neurobiol Dis 2014; 67: 79-87.

Geijselaers SL, Sep SJ, Stehouwer CD, Biessels GJ. Lancet Diabetes Endocrinol 2015; 3: 75-89.

Paramo B, Hernandez-Fonseca K, Estrada-Sanchez AM, et al. Neuroscience 2010; 167: 1057-1069.

Lee CW, Shih YH, Wu SY, et al. Curr Alzheimer Res 2013; 10: 298-308.

Suh SW, Hamby AM, Swanson RA. Glia 2007; 55: 1280-1286.

Fava S. Curr Diabetes Rev 2014; 10: 124-130.

Feinkohl I, Aung PP, Keller M, et al. Diabetes Care 2014; 37: 507-515.

Bruce DG, Davis WA, Casey GP, et al. Diabetologia 2009; 52: 1808-1815.

Matsuzaki T, Sasaki K, Tanizaki Y, et al. Neurology 2010; 75: 764-770.

Gray SM, Meijer RI, Barrett EJ. Diabetes 2014; 63: 3992-3997.

Haas CB, Kalinine E, Zimmer ER, et al. Mol Neurobiol 2016; 53 (9): 5807-5817.

Zemva J, Schubert M. CNS Neurol Disord Drug Targets 2014; 13: 322-337.

Martin ED, Sanchez-Perez A, Trejo JL, et al. Cereb Cortex 2012; 22: 1717- 1727.

de la Monte SM, Longato L, Tong M, Wands JR. Curr Opin Investig Drugs 2009; 10: 1049-1060.

Tokutake T, Kasuga K, Yajima R, et al. J Biol Chem 2012; 287: 35222-35233.

Russo E, Citraro R, Constanti A, De Sarro G. Mol Neurobiol 2012; 46: 662-681.

Xiang Q, Zhang J, Li CY, et al. Neuropeptides 2015; 54: 9-15.

Biessels GJ, Reagan LP. Nat Rev Neurosci 2015; 16: 660-671.

Costales J, Kolevzon A. Neurosci Biobehav Rev 2016; 63: 207-222.

Wang H, Qin J, Gong S, et a. Endocrinology 2014; 155: 168-179.

Huffman DM, Farias Quipildor G, Mao K, et al. Aging Cell 2016; 15: 181-186.

Hu A, Yuan H, Wu L, et al. Brain Res 2016; 1631: 204-213.

Banks WA. Eur J Pharmacol 2004; 490: 5-12.

Pushkarev VM, Sokolova LK, Pushkarev VV, Tron'ko ND. Probl Endokryn Patologii' 2016; 3: 77-90.

Liccini A, Malmstrom TK, Morley JE. J Am Med Dir Assoc 2016; 17 (11): 1063-1065.

Ng TP, Feng L, Yap KB, et al. J Alzheimers Dis 2014; 41: 61e68.

Hsu CC, Wahlqvist ML, Lee MS, Tsai HN. J Alzheimer’s Disease JAD 2011; 24: 485-493.

Hervás D, Fornés-Ferrer V, Gómez-Escribano AP, et al. PLoS One 2017; 12 (6): e0179283. doi: http://doi.org/10.1371/journal. pone. 0179283.

Zhao RR, Xu XC, Xu F, et al. Biochem Biophys Res Commun 2014; 448: 414-417.

Allard JS, Perez EJ, Fukui K, et al. Behav Brain Res 2016; 301: 1-9.

Chen F, Dong RR, Zhong KL, et al. Neuropharmacology 2016; 101: 123-136.

Huang YC, Hsu CC, Lin WC, et al. Sci World J 2014; 2014: 694326.

Imfeld P, Bodmer M, Jick SS, Meier CR. J Am Geriatr Soc 2012; 60: 916-921.

Moore EM, Mander AG, Ames D, et al. Diabetes Care 2013; 36: 2981-2987.

Luchsinger JA, Perez T, Chang H, et al. J Alzheimers Dis 2016; 51 (2): 501-514.

Thangthaeng N, Rutledge M, Wong JM, et al. Aging Dis 2017; 8 (1): 17-30.

Peixoto CA, Oliveira WH, Araújo SMDR, Nunes AKS. Exp Neurol 2017; 298 (Pt A): 31-41.

Mao-Ying QL, Kavelaars A, Krukowski K, et al. PLoS One 2014; 9 (6): e100701. doi: http://doi.org/10.1371/journal.pone.0100701.

Zhou W, Kavelaars A, Heijnen CJ. PLoS One 2016; 11 (3): e0151890. doi: http://doi.org/10.1371/journal.pone.0151890.

Hinduja S, Kraus KS, Manohar S, Salvi RJ. Neurotox Res 2015; 27 (3): 199-204.

Labuzek K, Suchy D, Gabryel B, et al. Pharmacol Rep 2010; 62: 956-965.

Markowicz-Piasecka M, Sikora J, Szydłowska A, et al. Pharm Res 2017; 34 (12): 2614-2627. doi: http://doi.org/10.1007/ s11095-017-2199-y.

Darvesh S. Curr Alzheimer Res 2016; 13 (10): 1173-1177.

Wang C, Liu C, Gao K, et al. Biochem Biophys Res Commun 2016; 477: 534-540.

Alzoubi KH, Khabour OF, Al-Azzam SI, et al. Curr Neuropharmacol 2014; 12: 186-192.

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Published

2021-08-18

How to Cite

Sokolova, L. K. ., Pushkarev, V. M. ., Pushkarev, V. V. ., Kovzun, E. I. ., & Tronko, N. D. . (2021). DIABETES MELLITUS AND COGNITIVE DYSFUNCTION. THE ROLE OF METFORMIN IN PATHOGENESIS AND TRE ATMENT OF COGNITIVE DYSFUNCTION (literature review). Problems of Endocrine Pathology, 64(2), 75-92. https://doi.org/10.21856/j-PEP.2018.2.10

Issue

Vol. 64 No. 2 (2018): Problems of Endocrine Pathology

Section

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