The role of zinc deficiency in the occurrence of thyroid gland pathology in children from environmentally unfavorable iodine deficiency areas

Authors

  • Kosmynina N.S. Danylo Halytskyy Lviv national medical university, Lviv, Ukraine
  • Lychkovska O.L. Danylo Halytskyy Lviv national medical university, Lviv, Ukraine
  • Malska A. A. Danylo Halytskyy Lviv national medical university, Lviv, Ukraine
  • Dats-Opoka M. I. Danylo Halytskyy Lviv national medical university, Lviv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.2.05

Keywords:

anthropogenic pollution, children, iodine deficiency, zinc.

Abstract

The article is devoted to the optimization of the system of treatment-and-prophylactic measures of ecologi­cally determined thyroid gland pathology in children. The state of the pituitary-thyroid system and the content of intracellular zinc in children living in ecologically unfavorable and at the same time iodine-deficient areas were examined and the improvement of the existing standard treatment regimens of eco-dependent pathology was proposed.

As a result of the conducted research, it was established that the state of iodine provision of children of the studied groups according to the median of iodin in urine corresponds to a deficiency of mild severity, and accord­ing to the frequency of goiter — to severe iodine deficiency. The discrepancy between the frequency of goiter and the median of iodin in urine can be explained by the influence of other environmental factors, along with iodine deficiency, affecting the formation of the endemic process in the region.

It has been established that children who, from birth, live in ecologically polluted areas, develop zinc defi­ciency both in cells and in blood serum, which is an informative indicator of the state of cellular metabolism and disorders caused by exogenous pollutants. In addition, it is shown that zinc deficiency in the body of children deepens the course and frequency of occurrence of diffuse endemic goiter among children living in environmen­tally polluted iodine-deficient areas. For medical correction of environmentally caused thyroid pathology in children living in polluted areas with iodine deficiency in the biosphere, it is recommended to add iodine and zinc in doses appropriate for the age to the therapy with membrane protectors, antioxidants and enterosorbents. Conducting standard therapy of ecopathology with the inclusion of potassium iodide helped reduce the frequency of goiter by 19%. Conducting standard therapy with simultaneous subsidies of potassium iodide and zinc sulfate significantly increased the effectiveness of treatment of children with clinical manifestations of ecopathology and contributed to the normalization of zinc in cells and serum and at the same time led to a 49% decrease in goiter frequency.

References

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Published

2021-06-30

How to Cite

Косминіна, . Н. С., Личковська, О. Л., Мальська, А. А., & Дац-Опока, М. І. (2021). The role of zinc deficiency in the occurrence of thyroid gland pathology in children from environmentally unfavorable iodine deficiency areas. Problems of Endocrine Pathology, 68(2), 34-39. https://doi.org/10.21856/j-PEP.2019.2.05

Issue

Section

CLINICAL ENDOCRINOLOGY