arterial hypertension, abdominal obesity, insulin resistance, cardio-metabolic factors


The aim: to study the relationship of insulin resistance (IR) with cardio-metabolic factors in patients with arterial hypertension (AH) with abdominal obesity (AO).

Materials and methods.The survey included 86 patients (50 men and 36 women) with essential  AH of 1-2-3 degrees (I-II stages) with AO of I-II degrees, aged 40 to 59 years. Patients were examined using standard clinical, laboratory and instrumental methods. IR was determined by calculating the HOMA index, and if the value of this index was >2.77, the presence of  IR was diagnosed. Data analysis was carried out using statistical processing using the computer program SPSS 19.0. for Windows XP.     Results. It was found that the vast majority of AH patients with AO (72%) were diagnosed with IR.  Among AH patients with AO and IR, in comparison with patients with normal insulin sensitivity, not only a significantly greater severity of obesity and the frequency of metabolic disorders (prediabetes, combined dyslipidemia, and reduced levels of high-density lipoprotein cholesterol in the blood) were revealed, but also a more severe course of AH: a significantly higher frequency of grade 3 and stage II hypertension, as well as lesions of target organs: left ventricular hypertrophy, in particular, concentric hypertrophy, thickening of the intima-media complex of the common carotid arteries and stage IIIa chronic kidney disease.      Conclusions.IR in AH patients with AO is a pathogenetically significant factor both in the development and progression of disorders of carbohydrate and lipid metabolism, and in AH.


Landsberg L. Obesity. In.: Hypertension: A Companion to Braunwald's Hear Disease. Third edition. G.L. Bakris, M.J. Sorrentino. 2018: 328-334.

Williams B, Mancia G, Spiering W et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018 Sep 1;39(33):3021-3104. doi: 10.1093/eurheartj/ehy339.

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice European Heart Journal. 2021. 00: 1-111. doi:10.1093/eurheartj/ehab484.

Hall J.E., do Carmo J.M., da Silva A.A., et al. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res. 2015;116(6):991-1006. doi:10.1161/CIRCRESAHA. 116.305697.

Koval S.M., Snihurska I.O., Vysotska O., Strashnenko H.M., Wójcik W., Dassibekov K. Prognosis of essential hypertension progression in patients with abdominal obesity. In book: Information Technology in Medical Diagnostics II, Wójcik, Pavlov& Kalimoldayev (Eds). London: Taylor&Francis Group, 2019. Р. 275-288. doi: 10.1201/9780429057618-32.

Redon J., Martinez F. and Pichler G. THE METABOLIC SYNDROME IN HYPERTENSION. In: Manual of Hypertension of the European Society of Hypertension. Third edition. Ed. by G. Mancia, G. Grassi, K.P. Tsioufis, A.F. Dominiczak, E. Agabiti Rosei. CRC Press.2019:: 135-147.

Коваль С.М., Резнiк Л.А., Старченко Т.Г., Пенькова М.Ю, Мисниченко О.В. Гендернi вiдмiнностi характеру харчування хворих працездатного вiку з ожирiнням та артерiальною гiпертензiею // Проблеми ендокринної патологiї.-2021.- № 3.-С.47-51.

Коваль С.М., Снiгурська I.О., Юшко К.О., Мисниченко О.В., Гальчинська В.Ю. Особливостi складу мiкробiоти кишечника у хворих на артерiальну гiпертензiю з абдомiнальним ожирiнням // Патологiя .-2021.- № 3.-С.303-310.

Місюра К. В., Манська К. Г. Особливості секреції мелатоніну й серотоніну у молодих жінок із різною масою тіла та їх взаємозв’язок з розвитком інсулінорезистентності. Міжнар. ендокринол. журн. 2019. Т. 15, № 6. С. 443-452.

Фадєєнко Г.Д., Грiднєв О.Е., Кушнiр I.Е. Ендотоксiнемiя у пацiентiв з ожирiнням та неалкогольною жировою хворобою печiнки // Проблеми ендокринної патологiї.-2021.- № 3.-С.76-82.

Koval S., Mysnichenko O., Snigurska I., Penkova M., Vysotskaya E., Bozhko V., Strashnenko A. Changes of vascular endothelial growth factor blood levels in patients with essential hypertension with and without abdominal obesity and stable angina pectoris. Journal of Hypertension. 2014. Vol. 32 (e-Suppl.1). P.172.

WHO: Obesity: Prevention and managing the global epidemic. Technical Report Series 894. Geneva: WHO; 2000.

Expert Panel of Detection, Evalution and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert (Adult treatment Panel III).JAMA; 2001May 16; 285 (19): 2486-2497.

Cosentino F, Grant PJ, Aboyans V et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020 Jan 7;41(2):255-323. doi: 10.1093/eurheartj/ehz486.

Bonora E. Homeostasis model assassment closely mirrors the glucose clamp techniqe in the assassment of insulin sensitivity : studies in subjects with various degrees of glucose tolerance and insulin sensitivity/ E.Bonora, G.Targher, M.Alberiche et al. // Diabetes Care.-2000.- Vol. 23.-P. 57..

Серцево-судинні захворювання. Класифікація, стандарти діагностики та лікування/За ред. В.М. Коваленка, М.І. Лутая, Ю.М. Сіренка, О.С. Сичова, 4-те вид., переробл. і доповн. - К.: МОРІОН, 2020. - 240 с.




How to Cite

Коваль, С., Снігурська, І., Мисниченко, О., & Літвінова, О. (2022). INSULIN RESISTANCE AND ITS RELATIONSHIPS WITH CARDIAC-METABOLIC FACTORS IN PATIENTS WITH ARTERIAL HYPERTENSION WITH OBESITY. Problems of Endocrine Pathology, 79(2), 32-38.