LEVELS OF VITAMIN D, HOMOCYSTEIN AND INCRE ASOR FUNCTION OF TESTAMENTS AMONG MALES WITH IDIOPATHIC PATOSPERM

Authors

DOI:

https://doi.org/10.21856/j-PEP.2021.1.03

Keywords:

vitamin D, homocysteine, idiopathic pathospermia, estradiol, testosterone

Abstract

The purpose of the research is to evaluate the levels of vitamin D and homocysteine in the blood of males with idiopathic pathospermia, taking into account the peculiarities of the endocrine function of their testes. The research studies levels of vitamin D, homocysteine, and sex hormones among 18 males with idiopathic pathospermia, aged 23–41, and among 7 males, of the same age, with the corresponding normal functional state of testes. The carried out correlation analysis does not reveal any dependence of homocysteine content on vitamin D levels in the infertile males’ blood. The study confirms that the males with idiopathic infertility have a significant decrease of the average blood level of vitamin D, an increase of the ascertaining D-vitamin deficiency frequency, as compared with the males without impaired spermatogenic and incretory testicular function. It is shown that under conditions of vitamin D deficiency in men with idiopathic pathospermia, there is a probable increase in the content of homocysteine in the blood. This indicates that vitamin D deficiency is likely a predictor of hyperhomocysteinemia, which contributes to the development of dyslipidemia and endothelial dysfunction. The authors state that together with ascertaining vitamin D deficiency among males with idiopathic pathospermia, there is a chance of an homocysteine increase in the blood — the predictor of the endothelial dysfunction formation. The research determines that the average values of testosterone in blood do not significantly differ from each other within the groups of infertile males with deficiency and insufficiency of vitamin D. The researchers conclude that vitamin D deficiency among males with idiopathic infertility is associated with an increase of the average estradiol blood level and a significant violation of the androgen-estrogen balance. This coincides with the literature, which suggests that vitamin D deficiency in men may be primarily a decrease in the ratio of testosterone to estradiol. The established negative changes in the conditions of D-hypovitaminosis can contribute to the deepening of spermatogenic dysfunction in men with idiopathic pathospermia, which must be taken into account when choosing approaches to their therapy.

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Published

2021-03-03

How to Cite

Bondarenko, V. A., Minukhin, A. S., & Skorniakov, E. I. (2021). LEVELS OF VITAMIN D, HOMOCYSTEIN AND INCRE ASOR FUNCTION OF TESTAMENTS AMONG MALES WITH IDIOPATHIC PATOSPERM. Problems of Endocrine Pathology, 75(1), 21-25. https://doi.org/10.21856/j-PEP.2021.1.03

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Section

CLINICAL ENDOCRINOLOGY

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