SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Authors

  • Tyzhnenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Atramentova L. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Karachentsev Y. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv; Kharkiv Postgraduate Medical Academy
  • Kravchun N. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Poltorak V. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy, Kharkiv
  • Jаnsen E. National Institute for Public Health and the Environment, Bilthoven
  • Leshchenko Zh. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gladkih O. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Krasova N. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Pochernyayev A. K. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Opaleiko Y. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Plohotnichenko O. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Zemlyanitcyna O. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Cherniaieva A. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Chernyavskaya I. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2014.3.01

Keywords:

type 2 diabetes, non-alcoholic fatty liver disease, adiponectin gene, a single nucleotide polymorphism

Abstract

It was studied the single nucleotide polymorphism (SNP) in the promoter region of –11391 G > A adiponectin gene (ADIPOQ) in patients with type 2 diabetes (n = 223) and healthy inhabitants of Kharkiv (n = 51). It was established the absence of significant differences in allele frequency for SNP –11391 G > A in patients with type 2 diabetes (pG = 0.856 pA = 0.144 ), diabetes mellitus patients complicated with non-alcoholic fatty liver disease (pG = 0.850 pA = 0.150 ) and healthy individuals (pG = 0.911 pA = 0.088 ). According to the results of the study the contribution of genetic components in the propensity formation for the development of non-alcoholic fatty liver disease in patients with diabetes in SNP –11391 G > A gene ADIPOQ was not identified. The data obtained have proved promising of further research, which should be based on a study of the role of other candidate genes in the development of non-alcoholic fatty liver disease and their relationship with various metabolic parameters which may allow clarifying the role of genes in disease formation

References

Spiegelman BM, Flier JS. Cell 2001; 104:531-543.

Saltiel AR. Nat Med 2001; 7:887-888.

Turer AT, Scherer PE. Diabetologia 2012; 55(9):2319-2326.

Goldstein BJ, Scalia R. J Clin Endocrinol Metab 2004; 89:2563-2568.

Francke S, Manraj M, Lacquemant C, et al. Hum Mol Genet 2001; 10(24):2751-2765.

Mtiraoui N, Ezzidi I, Turki A, et al. Diab Res Clin Pract 2012; 97(2):290-297.

Heid IM, Wagner SA, Gohlke H, et al. Diabetes 2006; 55(2):375-384.

Gibson F, Froguel P. Diabetes 2004; 53:2977-2983.

Kosobjan EP, Smirnova OM. Saharnyj Diabet 2010; 1:55-64.

Stefan N, Schafer S, Machicao F. J Clin Endocrinol Metab 2005; 90:4238-4243.

Kotronen A, Yki-Jarvinen H, Aminoff A, et al. Eur J Endocrinol 2009; 160:593-602.

Laumen H, Saningong AD, Heid IM, et al. Diabetes 2009; 58(4):984-991.

Rothenbacher D, Brenner H, März W, Koenig W. Europ Heart J 2005; 26(16):1640-1646.

Harvest FGu. Biomarker Insights 2009; 4:123-133.

Fruebis J, Tsao TS, Javorschi S, et al. Proc Natl Acad Sci USA 2001; 98(4):2005-2010.

Gu HF, Abulaiti a, Ostenson CG, et al. Diabetes 2004; 53(1):31-35.

Dolley G, Bertrais S, Frochot V, et al. Int J Obes (Lond) 2008; 32(4):669-675.

Chalasani N, Younossi Z, Lavine GE, et al. Hepatology 2012; 55(6):2005-2023.

Walsh PS, Metzger DA, Higuchi R. BioTechniques 1991; 10:506-513.

Solnceva AV, Aksenova EA, Sukalo AV, et al. Izv Nac Akad Nauk Belorusi 2011; 2:29-37.

Matthews DR, Hoske JP, Rudensk AS, et al. Diabetologia 1985; 28:412-419.

Katz A, Nambi SS, Mather K. et al. J Clin Endocrinol Metab 2000; 85:2402-2410.

Armitage P, Berry G. Statistical methods in medical research, Blackwell Scientific Publications, 1994: 620 p.

Warodomwichit D, Shen J, Arnett DK, et al. Obesity 2008:510-517.

Aksenova EA, Naumovich NI, Solnceva AV, et al. Genetychna i regeneratyvna medycyna: problemy ta perspektyvy: materialy nauk.-prakt. konf. z mizhnar. Uchastju, Kyi’v, 2010:13.

Bouatia-Naji N, David Meyre L, Stephane Lobbens L, et al. Diabetes 2006; 55:545-550.

Schraw T, Wang ZV, Halberg N, et al. Endocrinology 2008; 149:2270-2282.

Menzaghi C, Trischitta V, Doria A. Diabetes 2007; 56(5):1198-1209.

Oliveira CS, Saddi-Rosa P, Crispim F, et al. J Diab Compl 2012; 26(2):94-98.

Schwarz PE, Towers W, Fischer S, et al. Diabetes Care 2006; 29:1645-1650.

Wassel CL, Pankow, Jacobs DRJr, et al. Obesity 2010; 18(12):2333-2338.

Vasseur F, Helbecque H, Dina C, et al. Hum Mol Genet 2002; 11(21):2607-2614.

Schwarz PE, Govindarajalu S, Towers W, et al. Horm Metab Res 2006; 38(7):447-451.

Menzaghi C, Ercolino T, Salvemini L, et al. Physiological Genomics 2005; 19:170-174.

Morandi A, Maffeis C, Lobbens S, et al. Obesity 2010; 18(7):1469-1473.

Buzzetti R, Petrone A, Zavarella S, et al. Int J Obes (Lond) 2007; 31:424-428.

Fumeron F, Aubert R, Siddiq A, et al. Diabetes 2004; 53(4):1150-1157.

Enns JE, Taylor CG, Zahradka P. J Obes 2011:17.

Cook JR, Semple RK. J Clin Endocrinol Metab 2010; 95:1544-1554.

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Published

2014-10-27

How to Cite

Tyzhnenko, T. V., Atramentova, L. O., Karachentsev, Y. I., Kravchun, N. O., Poltorak, V. V., Gorshunska, M. Y., Jаnsen E., Leshchenko, Z. A., Gladkih, O. I., Krasova, N. S., Pochernyayev, A. K., Opaleiko, Y. A., Plohotnichenko, O. O., Zemlyanitcyna, O. V., Cherniaieva, A. O., & Chernyavskaya, I. V. (2014). SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. Problems of Endocrine Pathology, 49(3), 7-17. https://doi.org/10.21856/j-PEP.2014.3.01

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Section

CLINICAL ENDOCRINOLOGY

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