ANTIFIBROTIC EFFECT OF COMBINATION DAPAGLIFLOSIN AND METFORMIN THERAPY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND NON-ALCOHOLIC FATTY LIVER DISEASE
Keywords:diabetes mellitus, nonalcoholic fatty liver disease, hepatic fibrosis, scales for evaluation of level of fibrosis, treatment
45 patients with type 2 diabetes mellitus and NAFLD (27 males and 18 females) were examined. The therapy included dietary recommendations, administration of oral hypoglycaemic agents: dapaglyphosin in a daily dose of 10 mg and metformin in a daily dose of 1500–2000 mg, 7 patients were additionally prescribed insulin. The efficacy of the combination of dapaglyphosin and metformin for the treatment of patients with type 2 diabetes mellitus and NAFLD was shown. Improvement of carbohydrate metabolism, reduction of BMI and improvement of liver synthetic function were observed on the background of long-term administration of these drugs. A decrease of these patients liver fibrosis degree was found, which is confirmed by noninvasive markers of fibrosis, diagnostic indices and scales. The NAFLD scale was the most sensitive in diagnosis of liver fibrosis degree. Detection of a sufficiently large number of patients, the results of which can’t be unequivocally interpreted as the presence or absence of the risk of developing liver fibrosis, necessitates the development of another, more sensitive integrated scale that takes into account the features of the course of type 2 diabetes and contributed to reducing the direction of patients with liver biopsy for more a thorough diagnosis of the degree of fibrosis of this organ.
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