Ultrastructure of rat testicles after destructive exposure of the doxorubicin hydrochloride and the possibility of correction by chondroitin sulfate
DOI:
https://doi.org/10.21856/j-PEP.2018.3.05Keywords:
rat, ultrastructure of Sertoli and Leydig cells, chondroitin sulfate, cytostatics, doxorubicin hydrochlorideAbstract
The article have been presents data of the characteristic changes in the submicroscopic architectonics
of Sertoli and Leydig cells after destructive effect of the doxorubicin hydrochloride and possibility correction
of this state by chondroitin sulfate. It was shown that chondroitin sulfate promotes normalization condition
of submicroscopic organization of mitochondria, Sertoli and Leydig cells, the Golgi apparatus. There are
a reconstruction of cells bioenergetics processes and increase processes of piezobiosynthesis, which it leads
to activation of synthetic processes and repair of intracellular structures of animal’s testicles.
References
Gavriljuk AM, Chopjak VV, Nakonechnyj AI, Kurpish M. Med aspekty zdorov’ja muzhchiny 2012;3(1): 42-48.
Gorpinchenko II, Gurzhenko AJu. Zdorov’e muzhchiny 2010; 1: 28-32.
Ju Y, Yu A, Sun X, et al. Mol Med Rep 2013; 8 (3): 794- 798. https://doi.org/10.3892/mmr.2013.1584.
Brechka NM, Bondarenko VO, Korenjeva JeM, et al. Eksperym i klinich medycyna 2012; 3 (56): 52-58.
Patent 86662 UA. Sposib korekcii’ indukovanyh cytostatykom porushen’ spermatogenezu u shhuriv.
Holodkova OL. Osoblyvosti patogenezu porushen’ morfofunkcional’nogo stanu reproduktyvnoi’ systemy samciv ta samok eksperymental’nyh tvaryn ta i’h korekcija za dopomogoju regeneratyvnyh tehnologij, Odesa, 2010: 36 p.
Brechka NM, Nevzorov VP, Nevzorova OF, et al. Probl endokryn patologii’ 2014; 4: 67-77.