Perspectives of various hypotenzive combinations in treatment of artеrial hypertension with comorbid pathology

Authors

  • Shelest B. O. Kharkiv National Medical University, Kharkіv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2018.3.04

Keywords:

arterial hypertension, C-reactive protein, chemerin, diabetes, obesity

Abstract

It is discussed the results of the therapy of fixed three-component and non-fixed combinations, and its influence on endothelial function and inflammation in patients with arterial hypertension (AH) with comorbid pathology. It was shown that the 3 months usage of a three-component antihypertensive regimen led to a decrease by 14 % systolic and 11 % diastolic blood pressure. The ICAM-1 level decreased, and the total nitrogen oxide pool increased and was more pronounced with a fixed combination. Changes in chemerin and C-RB occurred in the same direction, with greater expressiveness when applied a fixed combination. The fixed combination can be considered as a preferred therapy for correction of endothelial dysfunction in hypertension with type 2 diabetes and obesity.

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Published

2021-07-06

How to Cite

Shelest, B. O. (2021). Perspectives of various hypotenzive combinations in treatment of artеrial hypertension with comorbid pathology . Problems of Endocrine Pathology, 65(3), 38-44. https://doi.org/10.21856/j-PEP.2018.3.04

Issue

Section

CLINICAL ENDOCRINOLOGY