The value of the tumor necrosis factor-alpha and vaspin ratio in the development of insulin resistance

Authors

  • Zhuravlyova L. V. Kharkiv National Medical University, Kharkiv, Ukraine
  • Pylov D. I. Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.3.15

Keywords:

vaspin, tumor necrosis factor alpha, adipocytokines, insulin resistance

Abstract

Diabetes mellitus type 2 is a chronic disease that results in metabolic disorders in the whole organism, primarily due to insulin resistance and relative insufficiency of insulin. The fatty tissue is no longer considered only as a passive depositary for the accumulation of energy and participation in the regulation of thermogenesis. In the last decades, it has been noted that this is an active endocrine organ that in addition to regulation of fat mass and participating in homeostasis, also releases a large number of bioactive mediators called adipokines. Adipokines are influenced by an autocrine or paracrine method on a variety of metabolic processes. Increased body weight is a factor in the development of different metabolic disorders. Excess fatty tissue can directly affect one of the main metabolic links — activity and insulin sensitivity. Increased body weight is a factor in the development of a carbohydrate metabolism disorder. Vaspin is an adipocytokine, a representative of widely spread serpins (serine protease inhibitors). The elevated serum protease inhibitor profile was noted in overweight and insulin-resistant mice. It is suggested that vaspin is an insulin sensitizer with anti-inflammatory action and can take part as a compensatory mechanism in response to reduced insulin sensitivity. Therefore, the activation of vaspin may decrease insulin resistance. Evaluation of protease which can be inhibited by vaspin may increase the development of new approaches of compensation based on etiology of impaired metabolic and glucose tolerance. The tumor necrosis factor-α (TNF-α) is a cytokine that is involved in systemic inflammation. The elevated levels of TNF-α are considered as one of the causative factors in insulin resistance, which is associated with obesity in the pathogenesis of DM-2. This review article provides an analysis of mostly foreign scientific articles about the importance of adipokines, particularly TNF-α and vaspin, in the development of insulin resistance and the possibility of further consideration of these markers as an indicator of the severity of the impaired carbohydrate metabolism.

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Published

2019-08-28

How to Cite

Zhuravlyova, L. V., & Pylov, D. I. (2019). The value of the tumor necrosis factor-alpha and vaspin ratio in the development of insulin resistance. Problems of Endocrine Pathology, 69(3), 113-120. https://doi.org/10.21856/j-PEP.2019.3.15